Clinical application of a new diastolic ventricular stiffness

新型舒张期心室僵硬度的临床应用

• 批准号: 09670762
• 负责人: SUGAWARA Motoaki
• 金额: $ 1.98万
• 依托单位: Tokyo Women's Medical University.
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670762/
• 关键词: diastolic function; stiffness.; stress.; echocardiography.; cardiac function.; ステッフネス; 新機能; 高血圧; 心肥大; 塩酸パパベリン

We have introduced a new method of evaluating regional stiffness of the left ventricle using the relation between mean wall stress (siguma) and the natural logarithm of reciprocal wall thickness [In(1/H)]. Left ventricular pressure and regional wall thickness were measured simultaneously, with a micromanometer-tipped catheter and by echocardiography. The siguma-In(1/H) relation was easily obtained from these data. The stiffness constant (K) was obtained by fitting the diastolic siguma-In(1/H) data points to an exponential curve with zero asymptote : siguma=C exp [KIn(1/H)]. K is defined for each region of concern, and independent of cardiac size. K should be useful for the comparison of myocardial stiffness among ventricles with differing size and between different pathological states in the same ventricle.With its ability to estimate regional diastolic myocardial stiffness, in addition to regional work and regional myocardial contractility, the method based on the siguma-In(1/H) relation should be valuable in assessing regional myocardial function quantitatively.

我们引入了一种利用平均壁应力 (siguma) 与壁厚倒数自然对数 [In(1/H)] 之间的关系来评估左心室区域刚度的新方法。使用微压计尖端导管和超声心动图同时测量左心室压力和局部壁厚度。从这些数据中很容易获得 siguma-In(1/H) 关系。通过将舒张期 siguma-In(1/H) 数据点拟合到渐近线为零的指数曲线来获得刚度​​常数 (K)：siguma=C exp [KIn(1/H)]。 K 是针对每个关注区域定义的，并且与心脏大小无关。 K对于比较不同大小的心室之间以及同一心室不同病理状态之间的心肌僵硬度应该是有用的。该方法除了能够估计局部舒张期心肌僵硬度之外，还能够估计局部做功和局部心肌收缩力。 siguma-In(1/H) 关系对于定量评估局部心肌功能应该有价值。

项目成果

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