Interaction between the Heart and Vascular System

心脏和血管系统之间的相互作用

基本信息

批准号：
11695092
负责人：
SUGAWARA Motoaki
金额：
$ 3.78万
依托单位：
Tokyo Woman's Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11695092/
关键词：
wave intensity cardiac contractility diastolic function reflected waves carotid artery ultrasound echo tracking color Doppler 心機能超音波法 wave intensity 負荷心臓

项目摘要

Wave intensity (WI) is a new index for evaluating ventriculo-arterial interactions. Wave intensity is defined as (dP/dt)(dU/dt) at any site of the circulation, where dP/dt and dU/dt are the time derivatives of blood pressure and velocity, respectively. Arterial wave intensity in normal subjects has two positive sharp peaks. The first peak occurs during early systole, the magnitude of which increases markedly with increases in cardiac contractility The second peak, which occurs towards the end of ejection, is related to the ability of the left ventricle to actively stop aortic blood flow and the compliance of the artery. During mid-ejection between the two positive peaks of WI, negative peaks are often observed. The magnitude and the timing of these peaks give information about the strength of wave reflections and the distance between the measuring point and the position of the reflections.We developed a new ultrasonic on-line system for obtaining WI, and assessed its validity. The system is composed of a computer, a WI unit and an ultrasonic machine (Aloka, Tokyo) equipped with a combined tissue imaging (5 or 7.5 MHz) and Doppler (5 MHz) transducer. The WI unit receives RF echo signals and color Doppler signals from the ultrasonic machine, and calculates the change in diameter of the artery (M-mode echo tracking) and the mean blood velocity through the sampling gate (color M-mode Doppler). Since arterial pressure waveforms and diameter change waveforms are similar, a blood pressure waveform is obtained from a diameter change waveform by calibrating its peak and bottom values by systolic and diastolic blood pressure measured with a cuff-type manometer.We investigated the characteristics of carotid arterial wave intensity in patients with heart disease.Wave intensity has the potential to provide meaningftil information about the working condition of the heart interacting with the arterial system.

波强度（WI）是评估心室-动脉相互作用的新指标。波强度定义为循环任意部位的 (dP/dt)(dU/dt)，其中 dP/dt 和 dU/dt 分别是血压和速度的时间导数。正常人的动脉波强度有两个正尖峰。第一个峰值出现在收缩早期，其幅度随着心肌收缩力的增加而显着增加。第二个峰值出现在射血末期，与左心室主动阻止主动脉血流的能力以及左心室的顺应性有关。动脉。在 WI 两个正峰值之间的射血中期，经常观察到负峰值。这些峰值的幅度和时间给出了有关波反射强度以及测量点和反射位置之间距离的信息。我们开发了一种新的超声在线系统来获取 WI，并评估了其有效性。该系统由计算机、WI 装置和配备组合组织成像（5 或 7.5 MHz）和多普勒（5 MHz）换能器的超声波机（Aloka，东京）组成。 WI单元接收来自超声波机的射频回波信号和彩色多普勒信号，并计算动脉直径的变化（M型回波跟踪）和通过采样门的平均血流速度（彩色M型多普勒）。由于动脉压力波形和直径变化波形相似，因此通过用袖带式压力计测量的收缩压和舒张压来校准其峰值和谷值，从而从直径变化波形获得血压波形。我们研究了颈动脉的特性心脏病患者的波强度。波强度有可能提供有关心脏与动脉系统相互作用的工作状况的有意义的信息。