Novel time-efficient inspiratory muscle strength training for lowering systolic blood pressure and improving endothelial, cerebrovascular, and cognitive function

新颖、省时的吸气肌力量训练，可降低收缩压并改善内皮、脑血管和认知功能

• 批准号: 10223434
• 负责人: Daniel Harrison Craighead
• 金额: $ 17.97万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10223434
• 关键词: Acute; Adherence; Adult; Aerobic Exercise; Age; Ascorbic Acid; Biological Availability; Biomedical Research; Biopsy; Blood Flow Velocity; Blood Pressure; Blood Vessels; Canada; Cardiovascular Diseases; Cardiovascular Physiology; Cerebrovascular Disorders; Cerebrovascular Physiology; Chronic; Chronic Disease; Clinical; Clinical Trials; Cognitive; Colorado; Conduct Clinical Trials; Consult; Data; Dementia; Development; Development Plans; Diastolic blood pressure; Doctor of Philosophy; Double-Blind Method; Dropout; Endothelial Cells; Endothelium; Environment; Epidemic; Extramural Activities; Faculty; Functional disorder; Funding; Goals; Guidelines; Hour; Hypercapnia; Hypertension; Impaired cognition; Infusion procedures; Inhalation; Internal carotid artery structure; International; Intervention; Journals; Link; Mediating; Medical; Medicine; Mentors; Molecular; Nature; Nitric Oxide; Obstructive Sleep Apnea; Oxidative Stress; Patients; Peripheral; Physiologic pulse; Physiological; Physiology; Population; Postdoctoral Fellow; Process; Production; Proteins; Protocols documentation; Randomized Clinical Trials; Records; Research; Research Personnel; Research Priority; Research Project Grants; Research Training; Resistance; Rest; Risk; Scientist; Secondary to; Serum; Signaling Molecule; Sodium-Restricted Diet; Stroke; Superoxides; Techniques; Time; Training; United States; United States National Institutes of Health; Universities; Vascular Diseases; Vascular Endothelium; Woman; Work; aged; arterial stiffness; base; blood pressure reduction; brachial artery; cardiovascular disorder risk; cardiovascular risk factor; career development; cerebral artery; cerebrovascular; clinically relevant; cognitive enhancement; cognitive function; cognitive performance; comorbidity; disorder risk; efficacy evaluation; efficacy testing; endothelial dysfunction; evidence base; experience; healthy lifestyle; improved; innovation; lifestyle intervention; meetings; men; middle cerebral artery; modifiable risk; muscle strength; novel; pilot trial; pressure; prevent; professor; programs; response; seal; skill acquisition; skills; strength training; therapy development; treatment duration

PROJECT SUMMARY CANDIDATE: Daniel H. Craighead, PhD, is a postdoctoral fellow training in integrative physiology at the University of Colorado (CU) Boulder. In this K01 application, Dr. Craighead aims to determine the efficacy of high-resistance inspiratory muscle strength training (IMST), a novel and time-efficient lifestyle intervention, for lowering systolic blood pressure (SBP) and improving endothelial, cerebrovascular, and cognitive function. His immediate goal is to acquire the research training and professional skills necessary to transition to an independent, extramurally funded investigator. His long-term goal is to establish his own research program with a focus on identifying novel, evidence-based lifestyle interventions that lower blood pressure and prevent or delay the development of blood pressure-associated comorbidities and chronic diseases. CAREER DEVELOPMENT PLAN: Dr. Craighead's career development plan consists of: 1) acquiring new skills to assess cerebrovascular and cognitive function to support his proposed research plan; 2) train in new cellular and molecular techniques to assess changes in oxidative stress and nitric oxide-bioavailability; and 3) professional skill development through coursework; attendance/presentations at weekly journal clubs, CU seminars, and national scientific meetings; and regular interactions with his mentor team. ENVIRONMENT: The environment for Dr. Craighead's training plan will be outstanding. Dr. Craighead's primary mentor, Dr. Douglas Seals, and co-mentor, Dr. Michel Chonchol, are internationally recognized, NIH-funded scientists with strong records of successful mentoring in translational biomedical research. Co-mentor, Dr. Fiona Bailey, performed the pioneering work on high-resistance IMST, making her the foremost expert of this novel lifestyle intervention. Consulting mentor Dr. Zhiying You is Senior Biostatistician in the Department of Medicine at the CU Anschutz Medical Campus and regularly provides mentoring/consulting to trainees and faculty conducting clinical trials. Consulting mentor Dr. Philip Ainslie is the Canada Research Chair in Cerebrovascular Physiology with extensive experience assessing cerebrovascular function. Consulting mentor Dr. Brianne Bettcher is an Assistant Professor at the CU Anschutz Medical Campus and expert in assessing cognitive function. RESEARCH: Above-normal SBP is a highly prevalent condition, afflicting the majority of adults over age 50. Above-normal SBP increases the risk for developing cardiovascular diseases, stroke, cognitive decline, and other chronic conditions. This increased risk is largely attributable to the development of vascular dysfunction in the peripheral and cerebral arteries, secondary to an increase in oxidative stress and consequent reduction in nitric oxide-bioavailability. Healthy lifestyle practices are first-line therapies to lower SBP and decrease disease risk; however, adherence to these practices is poor due to their time-intensive nature. The proposed research will test the efficacy of time-efficient, high-resistance IMST for promoting adherence, lowering SBP, and improving endothelial, cerebrovascular, and cognitive function in adults with above-normal SBP.

项目摘要 候选人：Daniel H. Craighead博士是综合生理学的博士后研究员 科罗拉多大学（CU）博尔德大学。在此K01应用程序中，Craighead博士旨在确定 高抗性的灵感肌肉力量训练（IMST）是一种新颖且耗时的生活方式干预措施 降低收缩压（SBP）并改善内皮，脑血管和认知功能。他的 直接目标是获得过渡到一个的研究培训和专业技能 独立的，外部资助的研究者。他的长期目标是建立自己的研究计划 重点是识别新颖的循证生活方式干预措施，以降低血压并防止 或延迟血压相关的合并症和慢性疾病的发展。职业 发展计划：Craighead博士的职业发展计划包括：1）获得新技能 评估脑血管和认知功能，以支持他提出的研究计划； 2）在新的蜂窝中训练 以及评估氧化应激和一氧化氮生物利用度变化的分子技术； 3） 通过课程开发专业技能； CU的每周期刊俱乐部的出勤/演示 研讨会和国家科学会议；以及与他的导师团队的定期互动。环境： Craighead博士的培训计划的环境将非常出色。 Craighead博士的主要导师，博士 道格拉斯·海豹（Douglas Seals）和联合官员米歇尔·康乔（Michel Chonchol 成功指导转化生物医学研究的有力记录。 fiona bailey博士， 在高级IMST上进行了开创性的工作，使她成为这款小说生活方式的最重要专家 干涉。咨询导师Zhiying博士您是医学系高级生物统计学家 Cu Anschutz医疗校园，并定期向学员和教职员工提供指导/咨询 临床试验。咨询导师Philip Ainslie博士是加拿大脑血管生理学研究主席 具有评估脑血管功能的丰富经验。咨询导师Brianne Bettcher博士是 Cu Anschutz医疗校园的助理教授和评估认知功能的专家。 研究：高于正常的SBP是一种高度普遍的状况，折磨了50岁以上的大多数成年人。 高于正常的SBP增加了患心血管疾病，中风，认知能力下降和 其他慢性病。这种增加的风险在很大程度上归因于血管功能障碍的发展 在周围和脑动脉中 在一氧化氮生物利用度中。健康的生活方式实践是降低SBP并减少的一线疗法 疾病风险；但是，由于它们的时间密集型性质，对这些做法的遵守是差的。提议 研究将测试时间效率高，高电压IMST的疗效，以促进依从性，降低SBP， 并改善了高度SBP的成年人的内皮，脑血管和认知功能。