Novel time-efficient inspiratory muscle strength training for lowering systolic blood pressure and improving endothelial, cerebrovascular, and cognitive function

新颖、省时的吸气肌力量训练，可降低收缩压并改善内皮、脑血管和认知功能

• 批准号: 10223434
• 负责人: Daniel Harrison Craighead
• 金额: $ 17.97万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10223434
• 关键词: Acute; Adherence; Adult; Aerobic Exercise; Age; Ascorbic Acid; Biological Availability; Biomedical Research; Biopsy; Blood Flow Velocity; Blood Pressure; Blood Vessels; Canada; Cardiovascular Diseases; Cardiovascular Physiology; Cerebrovascular Disorders; Cerebrovascular Physiology; Chronic; Chronic Disease; Clinical; Clinical Trials; Cognitive; Colorado; Conduct Clinical Trials; Consult; Data; Dementia; Development; Development Plans; Diastolic blood pressure; Doctor of Philosophy; Double-Blind Method; Dropout; Endothelial Cells; Endothelium; Environment; Epidemic; Extramural Activities; Faculty; Functional disorder; Funding; Goals; Guidelines; Hour; Hypercapnia; Hypertension; Impaired cognition; Infusion procedures; Inhalation; Internal carotid artery structure; International; Intervention; Journals; Link; Mediating; Medical; Medicine; Mentors; Molecular; Nature; Nitric Oxide; Obstructive Sleep Apnea; Oxidative Stress; Patients; Peripheral; Physiologic pulse; Physiological; Physiology; Population; Postdoctoral Fellow; Process; Production; Proteins; Protocols documentation; Randomized Clinical Trials; Records; Research; Research Personnel; Research Priority; Research Project Grants; Research Training; Resistance; Rest; Risk; Scientist; Secondary to; Serum; Signaling Molecule; Sodium-Restricted Diet; Stroke; Superoxides; Techniques; Time; Training; United States; United States National Institutes of Health; Universities; Vascular Diseases; Vascular Endothelium; Woman; Work; aged; arterial stiffness; base; blood pressure reduction; brachial artery; cardiovascular disorder risk; cardiovascular risk factor; career development; cerebral artery; cerebrovascular; clinically relevant; cognitive enhancement; cognitive function; cognitive performance; comorbidity; disorder risk; efficacy evaluation; efficacy testing; endothelial dysfunction; evidence base; experience; healthy lifestyle; improved; innovation; lifestyle intervention; meetings; men; middle cerebral artery; modifiable risk; muscle strength; novel; pilot trial; pressure; prevent; professor; programs; response; seal; skill acquisition; skills; strength training; therapy development; treatment duration

PROJECT SUMMARY CANDIDATE: Daniel H. Craighead, PhD, is a postdoctoral fellow training in integrative physiology at the University of Colorado (CU) Boulder. In this K01 application, Dr. Craighead aims to determine the efficacy of high-resistance inspiratory muscle strength training (IMST), a novel and time-efficient lifestyle intervention, for lowering systolic blood pressure (SBP) and improving endothelial, cerebrovascular, and cognitive function. His immediate goal is to acquire the research training and professional skills necessary to transition to an independent, extramurally funded investigator. His long-term goal is to establish his own research program with a focus on identifying novel, evidence-based lifestyle interventions that lower blood pressure and prevent or delay the development of blood pressure-associated comorbidities and chronic diseases. CAREER DEVELOPMENT PLAN: Dr. Craighead's career development plan consists of: 1) acquiring new skills to assess cerebrovascular and cognitive function to support his proposed research plan; 2) train in new cellular and molecular techniques to assess changes in oxidative stress and nitric oxide-bioavailability; and 3) professional skill development through coursework; attendance/presentations at weekly journal clubs, CU seminars, and national scientific meetings; and regular interactions with his mentor team. ENVIRONMENT: The environment for Dr. Craighead's training plan will be outstanding. Dr. Craighead's primary mentor, Dr. Douglas Seals, and co-mentor, Dr. Michel Chonchol, are internationally recognized, NIH-funded scientists with strong records of successful mentoring in translational biomedical research. Co-mentor, Dr. Fiona Bailey, performed the pioneering work on high-resistance IMST, making her the foremost expert of this novel lifestyle intervention. Consulting mentor Dr. Zhiying You is Senior Biostatistician in the Department of Medicine at the CU Anschutz Medical Campus and regularly provides mentoring/consulting to trainees and faculty conducting clinical trials. Consulting mentor Dr. Philip Ainslie is the Canada Research Chair in Cerebrovascular Physiology with extensive experience assessing cerebrovascular function. Consulting mentor Dr. Brianne Bettcher is an Assistant Professor at the CU Anschutz Medical Campus and expert in assessing cognitive function. RESEARCH: Above-normal SBP is a highly prevalent condition, afflicting the majority of adults over age 50. Above-normal SBP increases the risk for developing cardiovascular diseases, stroke, cognitive decline, and other chronic conditions. This increased risk is largely attributable to the development of vascular dysfunction in the peripheral and cerebral arteries, secondary to an increase in oxidative stress and consequent reduction in nitric oxide-bioavailability. Healthy lifestyle practices are first-line therapies to lower SBP and decrease disease risk; however, adherence to these practices is poor due to their time-intensive nature. The proposed research will test the efficacy of time-efficient, high-resistance IMST for promoting adherence, lowering SBP, and improving endothelial, cerebrovascular, and cognitive function in adults with above-normal SBP.

项目概要 候选人：丹尼尔·H·克雷格黑德 (Daniel H. Craighead) 博士，是一名博士后研究员，接受综合生理学培训 科罗拉多大学（CU）博尔德分校。在此 K01 应用中，Craighead 博士旨在确定以下药物的功效： 高阻吸气肌力量训练（IMST）是一种新颖且省时的生活方式干预措施， 降低收缩压（SBP）并改善内皮、脑血管和认知功能。他的 近期目标是获得过渡到大学所需的研究培训和专业技能 独立的、外部资助的调查员。他的长期目标是建立自己的研究计划 重点是确定新颖的、基于证据的生活方式干预措施，以降低血压和预防 或延缓与血压相关的合并症和慢性疾病的发展。职业 发展计划： Craighead 博士的职业发展计划包括： 1) 获得新技能 评估脑血管和认知功能以支持他提出的研究计划； 2）新细胞训练 和分子技术来评估氧化应激和一氧化氮生物利用度的变化；和 3) 通过课程作业发展专业技能；参加 CU 每周期刊俱乐部/发表演讲 研讨会和国家科学会议；以及与他的导师团队的定期互动。环境： 克雷格黑德博士的培训计划的环境将是非常出色的。克雷格黑德博士的主要导师，博士。 Douglas Seals 和联合导师 Michel Chonchol 博士是国际公认的、由 NIH 资助的科学家， 在转化生物医学研究方面拥有成功指导的良好记录。共同导师 Fiona Bailey 博士， 在高阻IMST方面做出了开创性的工作，使她成为这种新颖生活方式的首要专家 干涉。咨询导师游志英博士是医学部高级生物统计学家 CU Anschutz 医学校区定期为学员和教师提供指导/咨询 临床试验。咨询导师 Philip Ainslie 博士是加拿大脑血管生理学研究主席 具有丰富的脑血管功能评估经验。咨询导师 Brianne Bettcher 博士是 科罗拉多大学安舒茨医学院助理教授，认知功能评估专家。 研究：SBP 高于正常水平是一种非常普遍的疾病，困扰着大多数 50 岁以上的成年人。 收缩压高于正常水平会增加患心血管疾病、中风、认知能力下降和 其他慢性病。这种风险增加很大程度上归因于血管功能障碍的发展 在外周和脑动脉中，继发于氧化应激的增加和随之而来的减少 一氧化氮生物利用度。健康的生活方式实践是降低 SBP 和减少血压的一线疗法 疾病风险；然而，由于这些做法耗时，遵守率很低。拟议的 研究将测试省时、高阻力的 IMST 在促进依从性、降低收缩压、 改善收缩压高于正常成人的内皮、脑血管和认知功能。