Function of Wnt signaling in Hydra regeneration

Wnt信号在水螅再生中的作用

• 批准号: 88409386
• 负责人: Professor Dr. Thomas W. Holstein
• 金额: --
• 依托单位: Forschungsgruppe Molekulare Evolution und Genomik
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/88409386?language=en
• 关键词: Function; Wnt; signaling; Hydra; regeneration

Patterning processes during embryogenesis and regeneration probably share common regulatory mechanisms. However, only little is known which mechanisms act during both, normal development and regeneration, and how these mechanisms are activated. Based on new data in vertebrates and cnidarians we propose that signaling centers secreting Wnt ligands have a key role in the regeneration process. Here we want to identify the genetic mechanisms at the onset of the regeneration process in Hydra, i.e. mechanisms underlying the activation of canonical Wnt signaling and of downstream target genes. In combination with the sequenced genome, the Hydra system can therefore yield important new insights into the function of Wnt pathways in regulating regeneration.

胚胎发生和再生过程中的图案过程可能具有共同的调节机制。但是，几乎只知道哪些机制在正常发育和再生过程中起作用，以及如何激活这些机制。基于脊椎动物和CNIDARIAN中的新数据，我们提出，分泌Wnt配体的信号传导中心在再生过程中具有关键作用。在这里，我们要在Hydra的再生过程开始时确定遗传机制，即规范Wnt信号传导和下游靶基因激活的基础机制。因此，与测序的基因组结合使用，Hydra系统可以对Wnt途径在调节再生中的功能中产生重要的新见解。