Function of Wnt signaling in Hydra regeneration

Wnt信号在水螅再生中的作用

• 批准号: 88409386
• 负责人: Professor Dr. Thomas W. Holstein
• 金额: --
• 依托单位: Forschungsgruppe Molekulare Evolution und Genomik
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/88409386?language=en
• 关键词: Function; Wnt; signaling; Hydra; regeneration

Patterning processes during embryogenesis and regeneration probably share common regulatory mechanisms. However, only little is known which mechanisms act during both, normal development and regeneration, and how these mechanisms are activated. Based on new data in vertebrates and cnidarians we propose that signaling centers secreting Wnt ligands have a key role in the regeneration process. Here we want to identify the genetic mechanisms at the onset of the regeneration process in Hydra, i.e. mechanisms underlying the activation of canonical Wnt signaling and of downstream target genes. In combination with the sequenced genome, the Hydra system can therefore yield important new insights into the function of Wnt pathways in regulating regeneration.

胚胎发生和再生过程中的模式化过程可能具有共同的调节机制。然而，人们对哪些机制在正常发育和再生过程中起作用以及这些机制如何被激活知之甚少。基于脊椎动物和刺胞动物的新数据，我们提出分泌 Wnt 配体的信号传导中心在再生过程中发挥关键作用。在这里，我们想要确定水螅再生过程开始时的遗传机制，即经典 Wnt 信号传导和下游靶基因激活的机制。因此，结合测序的基因组，Hydra 系统可以对 Wnt 通路在调节再生中的功能产生重要的新见解。