The effects of aging- and menopausal related change in body fat distribution on life style associated diseases

衰老和更年期相关的身体脂肪分布变化对生活方式相关疾病的影响

基本信息

批准号：
09671701
负责人：
DOUCHI Tsutomu
金额：
$ 1.28万
依托单位：
Kagoshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

项目摘要

Objectives: To investigate the effects of aging- and menopausal related change in body fat distribution on lifestyle-associated diseases such as hyperlipidemia.Methods: Subjects were 482 premenopausal and 264 postmenopausal Japanese women. Age, height, weight, body mass index (BMI), menopausal status, years since menopause, and the presence or absence of physical exercise were recorded. Serum lipid levels including TC, TG, and HDL-C were measured. Trunk-leg fat ratio, percentage of body fat, and body fat mass were measured by dual-energy x-ray absorptiometry (QDR 2000).Results: Although trunk-leg fat ratio was positively correlated with age (r=0.464, P < 0.001), the correlations of BMI, percentage of body fat, and body fat mass with age were loose. On multiple regression analysis, only the trunk-leg fat ratio was significantly correlated with the presence of hyperlipidemia. Other variables were not significant predictors of hyperlipidemia. On stepwise multiple regression analysis, trunk-leg fat ratio was correlated with BMI (standardized regression coefficient =0.511, p < 0.0001), age (0.319, P < 0.0001), and menopausal status (0.109, p < 0.05). Trunk-leg fat ratio and percentage of body fat were significantly lower in physical exercising group than in controls (P <0.001 and 0.05, respectively).Conclusions: Menopause and aging independently induce upper body adiposity. Upper body fat distribution is the most important determinant of hyperlipidemia among the anthropometric variables. Aging- and menopausal related change in body fat distribution may be attributable to sedentariness with increasing age, decrease in ovarian steroids, less energy expenditure, and relatively high androgen environment.

目的：研究体内脂肪分布的衰老和绝经相关的变化对生活方式相关疾病（例如高脂血症）的影响。方法：受试者是482例绝经前和264名绝经后日本妇女。记录了年龄，身高，体重，体重指数（BMI），更年期状态，绝经后的年份以及体育锻炼的存在或不存在。测量包括TC，TG和HDL-C在内的血清脂质水平。通过双能量X射线吸收测定法测量躯干 - 腿脂肪比，体内脂肪的百分比和体内脂肪的量（QDR 2000）。分辨率：虽然树干 - 腿脂肪比与年龄呈正相关（r = 0.464，p <0.001），但BMI的相关性与体内脂肪的相关性和脂肪质量不足。在多元回归分析中，只有树干 - 腿脂肪比与高脂血症的存在显着相关。其他变量不是高脂血症的重要预测指标。在逐步多重回归分析中，树干 - 腿脂肪比与BMI（标准化回归系数= 0.511，p <0.0001），年龄（0.319，p <0.0001）和绝经状态（0.109，p <0.05）相关。在体育锻炼组中，躯干腿脂肪比和体内脂肪的百分比明显低于对照组（分别为p <0.001和0.05）。结论：更年期和衰老独立诱导上身肥胖。上身脂肪的分布是人体测量变量中高脂血症的最重要决定因素。体内脂肪分布的衰老和绝经相关的变化可能归因于随着年龄的增长，卵巢类固醇减少，能量消耗较少以及相对较高的雄激素环境的久坐性。