The effects of aging- and menopausal related change in body fat distribution on life style associated diseases

衰老和更年期相关的身体脂肪分布变化对生活方式相关疾病的影响

基本信息

批准号：
09671701
负责人：
DOUCHI Tsutomu
金额：
$ 1.28万
依托单位：
Kagoshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

项目摘要

Objectives: To investigate the effects of aging- and menopausal related change in body fat distribution on lifestyle-associated diseases such as hyperlipidemia.Methods: Subjects were 482 premenopausal and 264 postmenopausal Japanese women. Age, height, weight, body mass index (BMI), menopausal status, years since menopause, and the presence or absence of physical exercise were recorded. Serum lipid levels including TC, TG, and HDL-C were measured. Trunk-leg fat ratio, percentage of body fat, and body fat mass were measured by dual-energy x-ray absorptiometry (QDR 2000).Results: Although trunk-leg fat ratio was positively correlated with age (r=0.464, P < 0.001), the correlations of BMI, percentage of body fat, and body fat mass with age were loose. On multiple regression analysis, only the trunk-leg fat ratio was significantly correlated with the presence of hyperlipidemia. Other variables were not significant predictors of hyperlipidemia. On stepwise multiple regression analysis, trunk-leg fat ratio was correlated with BMI (standardized regression coefficient =0.511, p < 0.0001), age (0.319, P < 0.0001), and menopausal status (0.109, p < 0.05). Trunk-leg fat ratio and percentage of body fat were significantly lower in physical exercising group than in controls (P <0.001 and 0.05, respectively).Conclusions: Menopause and aging independently induce upper body adiposity. Upper body fat distribution is the most important determinant of hyperlipidemia among the anthropometric variables. Aging- and menopausal related change in body fat distribution may be attributable to sedentariness with increasing age, decrease in ovarian steroids, less energy expenditure, and relatively high androgen environment.

目的：调查衰老和更年期相关的身体脂肪分布变化对高脂血症等生活方式相关疾病的影响。方法：受试者为 482 名绝经前和 264 名绝经后日本女性。记录年龄、身高、体重、体重指数（BMI）、绝经状态、绝经年数以及是否进行体育锻炼。测量血清脂质水平，包括 TC、TG 和 HDL-C。采用双能X射线吸收仪（QDR 2000）测量躯干腿部脂肪比、体脂百分比和体脂肪量。结果：虽然躯干腿部脂肪比与年龄呈正相关（r=0.464，P < 0.001），BMI、体脂百分比和体脂肪量与年龄的相关性较松散。在多元回归分析中，只有躯干-腿部脂肪比与高脂血症的存在显着相关。其他变量并不是高脂血症的显着预测因素。在逐步多元回归分析中，躯干-腿部脂肪比与BMI（标准化回归系数=0.511，p <0.0001）、年龄（0.319，P <0.0001）和绝经状态（0.109，p <0.05）相关。体育锻炼组躯干腿部脂肪率和体脂百分比显着低于对照组（P<0.001和0.05）。结论：更年期和衰老独立诱发上半身肥胖。在人体测量变量中，上半身脂肪分布是高脂血症最重要的决定因素。衰老和更年期相关的身体脂肪分布变化可能归因于随着年龄的增长久坐、卵巢类固醇减少、能量消耗减少以及相对较高的雄激素环境。