Non-weight-bearing effect of trunk and peripheral fat mass on bone mineral density in pre-and post-menopausal women

躯干和周围脂肪量对绝经前后女性骨密度的非负重影响

基本信息

批准号：
21592140
负责人：
DOUCHI Tsutomu
金额：
$ 2.75万
依托单位：
Kagoshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592140/
关键词：
骨塩量内臓脂肪皮下脂肪液性因子エストロゲン非荷重効果

项目摘要

Objective : To investigate the non-weight-bearing effect of trunk fat mass(composed ofvisceral and subcutaneous fat mass) and peripheral fat mass(subcutaneous fat mass alone) on bone mineral density(BMD) in pre-and post-menopausal women.Methods : The subjects were 412 pre-menopausal women, 20. 50 years of age and 228post-menopausal women, 50. 75 years of age. Age, years since menopause(YSM), height, body weight, and body mass index were recorded. Trunk, peripheral(extremities), left arm(non-weight-bearing site), lean mass, and BMD were measured by dual-energy X-ray absorptiometry.Results : In pre-menopausal women, the amount of trunk fat mass was 6.8±4.1 kg, which was significantly lower than the amount of peripheral fat mass(11.6±3.8 kg, p<0.001). Although trunk fat mass was positively correlated with arm BMD on Pearson's correlation test, arm lean mass was the only significant predictor of BMD onmultiple regression analysis. In post-menopausal women, the amount of trunk fat mass(8.7±3.6 kg) was also significantly lower than the peripheral fat mass(10.3±3.4kg, p<0.001). On multiple regression analysis, however, trunk fat mass, but not arm lean mass, was the significant predictor of BMD. In both groups, peripheral fat mass was not correlated with left arm BMD.Conclusion : The effect of adipocyte-derived biochemical factors on BMD may differ with menopausal status and the sites of adipocyte deposition.

目的：探讨躯干脂肪量（由内脏脂肪量和皮下脂肪量组成）和外周脂肪量（仅皮下脂肪量）对绝经前后女性骨密度（BMD）的非负重作用。方法：研究对象为 412 名绝经前女性，年龄 20。 50 岁和 228 名绝经后女性，年龄 50。 75 岁。绝经后（YSM），通过双能X线测量躯干、外周（四肢）、左臂（非负重部位）、瘦体重和体重指数。结果：绝经前女性躯干脂肪量为6.8±4.1 kg，显着低于周围脂肪量（11.6±3.8 kg，尽管在皮尔逊相关性检验中躯干脂肪量与手臂 BMD 呈正相关，但在多元回归分析中，躯干脂肪量是 BMD 的唯一显着预测因子（8.7±）。 3.6千克）也显着低于外周脂肪量（10.3±3.4千克，p<0.001），然而，在多元回归分析中，躯干脂肪量而不是手臂瘦肉量是显着的。在两组中，外周脂肪量与左臂 BMD 无关。结论：脂肪细胞衍生的生化因素对 BMD 的影响可能因绝经状态和脂肪细胞沉积的部位而异。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

肥満症up date

肥胖更新日期

DOI：
发表时间：
2010
期刊：
肥満に伴う諸問題-病態と治療「肥満と婦人科疾患」綜合臨床
影响因子：
0
作者：
Fumitaka Saito;Hironori Tashiro;Hideyuki Ohtake;Takashi Ohba;and Hidetaka Katabuchi;堂地勉
通讯作者：
堂地勉

Large parasitic myomas in abdominal subcutaneous adipose tissue along a previous myomectomy scar

沿着之前的子宫肌瘤切除术疤痕，腹部皮下脂肪组织中存在大型寄生性肌瘤