Study on the difference in the relative contribution of lean and fat mass components to bone mineral density with generation.

研究瘦肉量和脂肪量成分对骨矿物质密度的相对贡献随一代的差异。

基本信息

批准号：
15591767
负责人：
DOUCHI Tsutomu
金额：
$ 1.79万
依托单位：
Kagoshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

AIM :To investigate whether the relative contribution of body composition (lean and fat mass component) to bone mineral density (BMD) differs depending on generation or menopause.METHODS :Subjects were 302 premenopausal women aged 30-49 years old and 197 postmenopausal women aged 50-69 years old. They were classified into four subgroups with 10-year increments. Age, height, weight and years since menopause (YSM) were recorded. Lumbar spine (L2-4), total body BMD, body fat mass, lean body mass (LBM), and the percentage of body fat (%fat) were measured using dual-energy X-ray absorptiometry. The correlation of body composition with BMD was investigated.RESULTS :The mean age at menopause was 50.2 +/- 4.1 years old. On Pearson's correlation test, LBM was positively correlated with BMD of the two sites in all groups. In a group aged 60-69 years, both the %fat and body fat mass were correlated with BMD. On multiple regression analysis, LBM was the principal BMD determinant in women aged less than 60 years, while body fat mass and percentage fat were the principal BMD determinants in women aged 60-69 years. Mean %fat in the group aged 60-69 years was 35.5 +/- 7.3%, which was significantly higher than that in the group aged 50-59 years (33.0 +/- 6.7%, P<0.05).CONCLUSION :Although LBM still influences BMD up to 10 years after menopause, the body fat mass initially influences BMD after 60 years of age. These differences may be attributable to certain aging-related factor(s).

目的：调查身体成分（瘦肉和脂肪成分）对骨矿物质密度 (BMD) 的相对贡献是否因世代或绝经期而异。方法：受试者为 302 名 30-49 岁的绝经前女性和 197 名 30-49 岁的绝经后女性。 50-69岁。他们被分为四个以 10 年为增量的亚组。记录年龄、身高、体重和绝经年数（YSM）。使用双能 X 射线吸收仪测量腰椎 (L2-4)、全身 BMD、体脂量、去脂体重 (LBM) 和体脂百分比 (%fat)。研究了身体成分与 BMD 的相关性。结果：绝经时的平均年龄为 50.2 +/- 4.1 岁。经Pearson相关性检验，所有组中LBM与两个部位的BMD均呈正相关。在 60-69 岁的人群中，脂肪百分比和体脂量均与 BMD 相关。多元回归分析显示，LBM是60岁以下女性BMD的主要决定因素，而体脂量和脂肪百分比是60-69岁女性BMD的主要决定因素。 60-69 岁组的平均脂肪百分比为 35.5 +/- 7.3%，显着高于 50-59 岁组（33.0 +/- 6.7%，P<0.05）。结论：尽管 LBM绝经后 10 年内仍然影响 BMD，体脂量在 60 岁后才开始影响 BMD。这些差异可能归因于某些与衰老相关的因素。

项目成果

期刊论文数量（82）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Menopause status influences the relationship between serumghrelin levels and fat mass in healthy women.

更年期状态影响健康女性血清生长素水平和脂肪量之间的关系。

DOI：
发表时间：
2005
期刊：
J Endocrinol Invest 28
影响因子：
0
作者：
T Kuramasu;K Doi;T Satoh;H Hibino;T Kubo.;Mizuma Nobuhisa;Iwamoto Ichiro;Yamasaki Hideki;Iwamoto Ichiro
通讯作者：
Iwamoto Ichiro

Discordance in the decline in regional lean and bone mass with advancing age.

随着年龄的增长，局部瘦肉和骨量下降的不一致。

DOI：
发表时间：
2005
期刊：
J Obstet Gynaecol Res 31
影响因子：
0
作者：
T Kuramasu;K Doi;T Satoh;H Hibino;T Kubo.;Mizuma Nobuhisa;Iwamoto Ichiro;Yamasaki Hideki;Iwamoto Ichiro;Iwamoto Ichiro;Kuwahata Riki
通讯作者：
Kuwahata Riki

Use of heparin to lower the incidence of phlebitis induced by anti-neoplastic agents used in ovarian cancer.

使用肝素降低卵巢癌抗肿瘤药物引起的静脉炎的发生率。

DOI：
发表时间：
2004
期刊：
Journal of Obstetrics and Gynaecology Research 30
影响因子：
0
作者：
Ikeda T;Douchi T;Nagata Y
通讯作者：
Nagata Y

Zinc finger domain of Snail function as a nuclear localization signal for important β-mediated nuclear import pathway.

Snail 的锌指结构域作为重要 β 介导的核输入途径的核定位信号。

DOI：
发表时间：
2005
期刊：
Genes to Cell 10
影响因子：
0
作者：
T Kuramasu;K Doi;T Satoh;H Hibino;T Kubo.;Mizuma Nobuhisa;Iwamoto Ichiro;Yamasaki Hideki
通讯作者：
Yamasaki Hideki

Overian hyperstimulation syndrome associated with tamoxifen therapy in premenopausal breast cancer patients.

绝经前乳腺癌患者与他莫昔芬治疗相关的 Overian 过度刺激综合征。

DOI：
发表时间：
2004
期刊：
The Kagoshima District Journal of the Japanese Obstetrical and Gynecological Society 12
影响因子：
0
作者：
T Kuramasu;K Doi;T Satoh;H Hibino;T Kubo.;Mizuma Nobuhisa;Iwamoto Ichiro;Yamasaki Hideki;Iwamoto Ichiro;Iwamoto Ichiro;Kuwahata Riki;Nakae Mitsuhiro;Mizuma Nobuhisa;Iwamoto Ichiro;Nakae Mistuhiro;Douchi Tsutomu;Iwamoto Ichiro;Douchi Tsutomu;Iwamoto Ichiro;Nakae Mitsuhiro
通讯作者：
Nakae Mitsuhiro