Development of the mouse model with 24-hour rhythm disturbances

24小时节律紊乱小鼠模型的建立

• 批准号: 09672330
• 负责人: OHDO Shigehiro
• 金额: $ 1.86万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09672330/
• 关键词: Biological Rhythm; Chronopharmacology; Pharmacokinetics; Interferon; Suprachiasmatic nuclei; mouse; 視交叉上核

The effectiveness and toxicity of many drugs vary depending on the dosing schedule associated with the twenty-four hour rhythms of biochemical, physiological and behavioral processes. In contrast, several drugs can cause alterations to the twenty-four hour rhythms, which leads to illness and altered homeostatic regulation. However, the mechanism has not been clarified from the viewpoint of the disruptive effect of the drugs on clock genes. Here, we show the disruptive effect of interferon- α on the rhythm of locomotor activity, body temperature and clock genes mRNA expression in the periphery and suprachiasmatic nuclei, a primary circadian pacemaker. The rhythmicity of clock genes and the photic induction of the mPer1 gene in suprachiasmatic nuclei were disturbed by the repetitive administration of interferon- α. Furthermore, alteration of the clock function, a new concept of adverse effects, can be overcome by devising a dosing schedule that minimizes adverse drug effects on clock function. Thus I developed the mouse model with twenty-four hour rhythm disturbances induced by interferon.

效率和毒药根据生物化学的二十四小时节奏而变化从这里的药物的角度来看，我们显示了盘中活性，体温和时钟基因MRNES mRNAS mRNA在周围和上的核心核中，这是昼夜节律的基因。 MP的MP核核中的ER1基因受到干扰素α的重复施用。干扰素引起的干扰。

项目成果

Shigehiro Ohdo et al: "Circadian rhythm of fever induced by interferon-α."Life Sciences. 61 8. PL95-100 (1997)

Shigehiro Ohdo 等人：“干扰素-α 引起的发热的昼夜节律”。生命科学，61 8。PL95-100 (1997)。

Shigehiro Ohdo et al: "Basis for dosing time-dependent changes in the antiviral activity of interferon-α in Mice"The Journal of Pharmacology and Experimental Therapeutics. 294・2. 488-493 (2000)

Shigehiro Ohdo 等人：“小鼠中干扰素-α 的抗病毒活性的给药时间依赖性变化的基础”药理学和实验治疗学杂志 294·2（2000）。

Satoru Koyanagi et al: "Chronopharmacological study of interferon-α in mice"The Journal of Pharmacology and Experimental Therapeutics. 283・1. 259-264 (1997)

Satoru Koyanagi 等：“小鼠干扰素-α 的时间药理学研究”药理学和实验治疗学杂志 283·1（1997）。

Shigehiro Ohdo et al: "Circadian rhythm of fever induced by interferon-α in mice"Life Sciences. 61・8. PL95-100 (1997)

Shigehiro Ohdo 等人：“干扰素-α 引起小鼠发热的昼夜节律”生命科学 61・8（1997 年）。

Satoru Koyanagi et al: "Chronopharmacological study of interferon-α in mice."The Journal of Pharmacology and Experimental Therapeutics. 283 1. 259-264 (1997)

Satoru Koyanagi 等人：“小鼠干扰素-α 的时间药理学研究”。《药理学和实验治疗学杂志》283 1. 259-264 (1997)。