Role of molecular clock on the communication between each organ in organ dysfunction

分子钟在器官功能障碍中各器官之间通讯的作用

• 批准号: 23659084
• 负责人: OHDO Shigehiro
• 金额: $ 2.41万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659084/
• 关键词: 生体リズム; 分子時計; 臓器障害; 合併症

Chronic kidney disease (CKD) increases the disease risk of apoplexy, cardiac failure, cardiac infarction and neurological complications. However, the mechanisms of these neurological complications remain unclear. Here, we showed the disruptive effect of chronic renal failure in 5/6 nephrectomy mice on the 24-hr rhythm of dopamine receptor and clock gene expressions in the striatum and cytochrome P450 (CYPs) in liver. These disruptive effects were induced by abnormal signal transduction in high Factor X expression from the kidney.

慢性肾脏疾病（CKD）增加了中风，心力衰竭，心脏梗塞和神经系统并发症的疾病风险。但是，这些神经系统并发症的机制尚不清楚。在这里，我们在5/6肾切除术小鼠中显示了慢性肾衰竭对多巴胺受体的24小时节奏和肝脏中的纹状体P450（CYP）中的24小时节奏的破坏作用。这些破坏性效应是通过肾脏高因子X表达异常的信号转导引起的。