Regulating the composition of biomolecular condensates in living cells

调节活细胞中生物分子凝聚物的组成

• 批准号: DP240102533
• 负责人: Dr Scott Berry
• 金额: $ 38.77万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102533
• 关键词: Regulating; composition; biomolecular; condensates; living

Biomolecular condensation is a novel organising principle of living cells, driven by ‘unmixing’ of the cellular contents into compartments. It is observed from plants to animals and is involved in diverse processes from how cells repair DNA to how they perceive signals. This project aims to reveal how human cells control the composition of condensates, which is critical for their function. It expects to uncover new regulatory principles of cellular organisation by combining methods from quantitative cell biology and statistical physics. Expected benefits include building Australia’s capability in the potentially transformational field of biomolecular condensates, which has diverse future biotechnology applications in health and agriculture.

生物分子凝聚是活细胞的一种新颖的组织原理，由细胞内容物“分解”成区室所驱动，从植物到动物都观察到它，并且涉及从细胞如何修复 DNA 到它们如何感知信号的多种过程。揭示人类细胞如何控制凝聚物的组成，这对其功能至关重要，它期望通过结合定量细胞生物学和统计物理学的方法来揭示细胞组织的新调控原理，预期的好处包括增强澳大利亚在潜在变革方面的能力。生物分子凝聚体领域，未来生物技术在健康和农业方面有多种应用。