Development of new joint markers for osteoarthritis

开发骨关节炎的新关节标记物

• 批准号: 23592224
• 负责人: SAITO Tomoyuki
• 金额: $ 3.08万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592224/
• 关键词: 変形性関節症; 関節マーカー; 変形性膝関節症

The purpose of this study is to elucidate pathogenesis of osteoarthritis and to evaluate therapeutic efficacy using joint markers. Clinical status and joint markers were improved by intra-articular injection of hyaluronic acid for patients with osteoarthritis of the knee. Reduction of IL-6 suggests inhibitory effect of hyaluronic acid on inflammation and IL-6 seems to be a novel joint marker to assess progression and therapeutic efficacy for osteoarthritis. Increased number of blood vessels was shown in synovial tissue and increased expressions of angiogenesis-related factors were investigated. These factors contributing to progression of osteoarthritis are also possible joint markers for osteoarthritis.

本研究的目的是阐明骨关节炎的发病机制并利用关节标志物评估治疗效果。通过关节内注射透明质酸改善膝骨关节炎患者的临床状态和关节标志物。 IL-6 的减少表明透明质酸对炎症具有抑制作用，IL-6 似乎是评估骨关节炎进展和治疗效果的新型关节标志物。滑膜组织中血管数量增加，并且研究了血管生成相关因子的表达增加。这些导致骨关节炎进展的因素也可能是骨关节炎的关节标志物。

项目成果

Fractures around the lateral cortical hinge after a medial opening-wedge high tibial osteotomy : a new classification of lateral hinge fracture

胫骨内侧开口楔形高位截骨术后外侧皮质铰链周围骨折：外侧铰链骨折的新分类

• 发表时间: 2012
• 影响因子: 4.7
• 作者: Takeuchi R; Ishikawa H; Kumagai K; Yamaguchi Y; Chiba N; Akamatsu Y; Saito T
• 通讯作者: Saito T

専門医のための疾患・外傷診療ガイド変形性膝関節症(特発性骨壊死を含む)

疾病和创伤专家治疗指南膝骨关节炎（包括特发性骨坏死）

• 发表时间: 2012
• 作者: 齋藤知行; 熊谷研
• 通讯作者: 熊谷研

The extent of degeneration of cruciate ligament is associated with chondrogenic differentiation in patients with osteoarthritis of the knee

膝骨关节炎患者十字韧带退变程度与软骨分化相关

• 发表时间: 2013
• 作者: Kumagai K; Sakai K; Kusayama Y; Akamatsu Y; Saito T; Sakai T
• 通讯作者: Sakai T

Five- to ten-year outcome following medial opening-wedge high tibial osteotomy with rigid plate fixation in combination with an artificial bone substitute.

内侧开口楔形高位胫骨截骨术结合刚性钢板固定和人工骨替代物后的五到十年结果。

• DOI: 10.1302/0301-620x.96b3.32525
• 发表时间: 2014
• 影响因子: 4.6
• 作者: Saito T; Kumagai K; Akamatsu Y; Kobayashi H; Kusayama Y.
• 通讯作者: Kusayama Y.

変形性膝関節症における保存的治療の限界・手術的治療の適応.変形性膝関節症の運動療法ガイド

膝骨关节炎保守治疗的局限性和手术治疗的适应症。膝骨关节炎的运动治疗指南。

• 发表时间: 2014
• 作者: 齋藤知行; 熊谷研
• 通讯作者: 熊谷研