Tailored silver nanoparticles (NPs) in biological environments: Interactions with biomolecules and cells (nano.ag)

生物环境中的定制银纳米颗粒 (NP)：与生物分子和细胞的相互作用 (nano.ag)

• 批准号: 57812932
• 负责人: Professor Dr. Matthias Epple
• 金额: --
• 依托单位: Physikalische Chemie - AG Zellner
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/57812932?language=en
• 关键词: Tailored; silver; nanoparticles; NPs; biological

Silver nanoparticles represent the class of nanoparticles with the highest commercial impact, being used in consumer commodities, textiles and medical equipment due to their bactericidal potential. The biological action of self-synthesized and thoroughly characterized silver nanoparticles will be investigated at various levels: Their interaction with biomolecules, their entrance into cells, the mechanism of their biological action, the dissolution under release of silver ions, and their fate in the cell after uptake and internalization. These investigations will be carried out under variation of the kind of surface functionalization and the size of the silver nanoparticles. For comparison, gold nanoparticles as a biologically inert material with the same surface functionalization and size will be tested by the same methods.

银纳米粒子代表了具有最高商业影响力的纳米粒子类别，由于其杀菌潜力而被用于消费品、纺织品和医疗设备。自我合成和彻底表征的银纳米颗粒的生物作用将在各个层面进行研究：它们与生物分子的相互作用、它们进入细胞、它们的生物作用机制、银离子释放下的溶解以及它们在细胞中的命运吸收和内化后。这些研究将在表面功能化类型和银纳米粒子尺寸的变化下进行。为了进行比较，将通过相同的方法测试具有相同表面功能化和尺寸的生物惰性材料金纳米粒子。