Bimetallic nanoparticles of the platinum metals (Ru, Rh, Pd, Os, Ir, Pt) and of silver: Synthesis, microstructure, and biological action

铂族金属（Ru、Rh、Pd、Os、Ir、Pt）和银的双金属纳米颗粒：合成、微观结构和生物作用

• 批准号: 286659497
• 负责人: Professor Dr. Matthias Epple
• 金额: --
• 依托单位: Ernst Ruska-Centrum für Mikroskopie und Spektroskopie mit Elektronen
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/286659497?language=en
• 关键词: Bimetallic; nanoparticles; platinum; metals; Ru

Bimetallic nanoparticles on the basis of silver and platinum metals shall be wet-chemically prepared and subsequently analysed with respect to their microstructure. Besides colloid-chemical methods and elemental analysis, especially high-resolution transmission electron microscopy shall be applied. The distribution of the elements in the nanoparticles will be spatially and quantitatively determined. By variation of the synthesis parameters, the internal structure and the size of the nanoparticles will be adjusted. Based on the principle of a sacrificial anode, the release of silver ions shall be enhanced in comparison to pure silver nanoparticles. This will be quantitatively measured with selected nanoparticle compositions. The influence of the composition of the particles, their microstructure and their size on bacteria and cells will be studied. The goal is to achieve a maximal and selective antibacterial effect together with low cytotoxicity and small total amount of silver. The emphasis will be laid on the mechanistic understanding of the antibacterial and cytotoxic action.

基于银和铂金属的双金属纳米粒子应采用湿化学方法制备，并随后对其微观结构进行分析。除胶体化学方法和元素分析外，尤其应应用高分辨率透射电子显微镜。纳米颗粒中元素的分布将在空间上和定量上确定。通过改变合成参数，可以调整纳米颗粒的内部结构和尺寸。基于牺牲阳极的原理，与纯银纳米粒子相比，银离子的释放会增强。这将用选定的纳米颗粒组合物进行定量测量。将研究颗粒的组成、微观结构和尺寸对细菌和细胞的影响。目标是实现最大的选择性抗菌效果，同时具有低细胞毒性和少量的银总量。重点将放在对抗菌和细胞毒性作用的机制理解上。