Comprehensive study of hepatitis B virus genotypes and mutations involved in the pathogenesis

乙型肝炎病毒基因型及突变参与发病机制的综合研究

• 批准号: 22790627
• 负责人: INOUE Jun
• 金额: $ 2.33万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790627/
• 关键词: 肝臓学; ウイルス性肝炎

To investigate hepatitis B virus (HBV)genotypes and mutations that are involved in the pathogenesis, full-genome analysis of genotype B1/Bj HBV, which is known to occur fulminant hepatitis frequently, was performed. Interestingly, single nucleotide insertion/deletion that causes frameshift in the precore region was found frequently in fulminant hepatitis strains. Furthermore, amino acid 21 mutation in the core protein was also found frequently. In vitro studies clarified that HBV with these insertion/deletion/mutation showed high replication capacity. These findings might clarify a part of fulminant hepatitis pathogenesis.

为了调查乙型肝炎病毒（HBV）的基因型和与发病机制有关的突变，对已知经常发生暴发性肝炎的基因型 B1/Bj HBV 进行了全基因组分析。有趣的是，在暴发性肝炎毒株中经常发现导致前核心区域移码的单核苷酸插入/缺失。此外，核心蛋白21位氨基酸突变也频繁被发现。体外研究表明，具有这些插入/缺失/突变的乙型肝炎病毒表现出高复制能力。这些发现可能澄清暴发性肝炎发病机制的一部分。

项目成果

B型劇症肝炎におけるgenotype, precore領域frameshiftの意義

暴发性乙型肝炎基因型和前核心区移码的意义

• 发表时间: 2010
• 作者: 井上淳; 上野義之; 下瀬川徹
• 通讯作者: 下瀬川徹

Four-year study of lamivudine and adefovir combination therapy in lamivudine-resistant hepatitis B patients : Influence of hepatitis B virus genotype and resistance mutation pattern

拉米夫定和阿德福韦联合治疗拉米夫定耐药乙型肝炎患者的四年研究：乙型肝炎病毒基因型和耐药突变模式的影响

• 发表时间: 2011
• 影响因子: 2.5
• 作者: Inoue J; Ueno Y; Wakui Y; Niitsuma H; Fukushima K; Yamagiwa Y; Shiina M; Kondo Y; Kakazu E; Tamai K; Obara N; Iwasaki T; Shimosegawa T.
• 通讯作者: Shimosegawa T.

Management of chronic hepatitis B patients : Efficacy & limitation of nucleos(t)ide analogues

慢性乙型肝炎患者的管理：疗效

• 发表时间: 2011
• 影响因子: 4.2
• 作者: Inoue J; Ueno Y; Shimosegawa T
• 通讯作者: Shimosegawa T

Inhibitory effect on hepatitis B virus in vitro by a peroxisome proliferator-activated receptor-γ ligand, rosiglitazone

过氧化物酶体增殖物激活受体-γ配体罗格列酮对乙型肝炎病毒的体外抑制作用

• 发表时间: 2010
• 影响因子: 3.1
• 作者: Wakui Y; Inoue J; Ueno Y; Fukushima K; Kondo Y; Kakazu E; Obara N; Kimura O; Shimosegawa T
• 通讯作者: Shimosegawa T

Enhanced replication of hepatitis B virus with frameshift in the precore region found in fulminant hepatitis patients

在暴发性肝炎患者中发现乙型肝炎病毒复制增强，并伴有前核心区移码

• 发表时间: 2011
• 作者: Inoue J; Ueno Y; Wakui Y; Fukushima K; Kondo Y; Kakazu E; Ninomiya M; Niitsuma H; Shimosegawa T
• 通讯作者: Shimosegawa T