A study of the ameliorative activity of 2-decenoic acid ester derivatives on the spinal cord injury and its medical application

2-癸烯酸酯衍生物改善脊髓损伤的活性研究及其医药应用

• 批准号: 22390293
• 负责人: FURUKAWA Shoei
• 金额: $ 12.31万
• 依托单位: Gifu Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390293/
• 关键词: 脊髄損傷; 軸索再生; 運動機能回復; デセン酸誘導体; 神経栄養因子; シグナル伝達; 培養神経細胞; 神経再生; 遺伝子発現

Oral administration of (E)-N-2-(dimethylamino) ethyl dec-2-enamide, a novel 2-decenoic acid compound, to the rats with a complete transection of the spinal cord injury, markedly improved locomotor activity after 3 weeks. The animals treated with the compound could nearly walk sustaining their weight in hind limb, but the control ones without treatment remained unchanged, demonstrating that the locomotor function impaired following the spinal cord injury could be markedly recovered by oral administration of the 2-decenoic acid derivatives.

给脊髓完全横断损伤的大鼠口服(E)-N-2-(二甲氨基)乙基癸-2-烯酰胺(一种新型2-癸烯酸化合物)，3周后运动活性显着改善。用该化合物治疗的动物几乎可以行走并维持其后肢的重量，但未治疗的对照动物则保持不变，这表明口服2-癸烯酸衍生物可以显着恢复脊髓损伤后受损的运动功能。

项目成果

2-Decenoic acid ethyl ester possesses neurotrophin-like activities to facilitate intracellular signals and increase synapse-specific proteins in neurons cultured from embryonic rat brain

2-癸烯酸乙酯具有神经营养蛋白样活性，可促进细胞内信号并增加从胚胎大鼠脑培养的神经元中的突触特异性蛋白

• 发表时间: 2010
• 作者: Makino A; Iinuma M; Fukumitsu H; Soumiya H; Furukawa Y; Furukawa S
• 通讯作者: Furukawa S

神経栄養因子シグナルの活性化に基づく新規アルツハイマー病治療薬(新規デセン酸誘導体)

基于神经营养因子信号激活的新型阿尔茨海默病治疗（新型癸烯酸衍生物）

• 发表时间: 2013
• 作者: 古川昭栄

Medium-chain fatty acid-containing dietary oil alleviates the depression-like behaviour in mice exposed to stress due to chronic forced swimming.

含有中链脂肪酸的膳食油可以缓解因长期强迫游泳而承受压力的小鼠的抑郁样行为。

• 发表时间: 2013
• 作者: Shinohara H

Prenatal immune challenge compromises development of upper-layer but not deeper-layer neurons of the mouse cerebral cortex

产前免疫挑战会损害小鼠大脑皮层上层神经元的发育，但不会损害深层神经元的发育

• DOI: 10.1002/jnr.22636
• 发表时间: 2011
• 影响因子: 4.2
• 作者: Soumiya H; Fukumitsu H; Furukawa S
• 通讯作者: Furukawa S

FGF-2-responsive and spinal cord-resident cells improve locomotor function after spinal cord injury.

FGF-2 反应性脊髓驻留细胞可改善脊髓损伤后的运动功能。

• 发表时间: 2010
• 作者: Kasai M; Jikoh T; Fukumitsu H; Furukawa S
• 通讯作者: Furukawa S