Infant Brain and Behavioral Signatures of Later Emerging Risk for Psychopathology

婴儿大脑和后来出现的精神病理学风险的行为特征

基本信息

批准号：
9085449
负责人：
Jed Thomas Elison
金额：
$ 51.93万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-29 至 2019-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9085449
关键词：
Acceleration Adaptive Behaviors Age Age-Months Anxiety Disorders Arousal Attention deficit hyperactivity disorder Autacoids Autistic Disorder Behavior Behavior assessment Behavioral Biological Psychiatry Brain Brain imaging Brain region Child Child Behavior Checklist Clinical Cognitive Complement Coupled Data Development Developmental Process Diagnostic and Statistical Manual of Mental Disorders Disease Early Intervention Early identification Emotional Event Eye Foundations Functional Magnetic Resonance Imaging Functional disorder Future Goals Head Health Human Individual Differences Infant Interview Life Link Longevity Maps Mental disorders Mood Disorders National Institute of Mental Health Neurodevelopmental Disorder Neurosciences Neurosciences Research Nursery Schools Outcomes Research Parents Participant Pathway interactions Pattern Preschool Child Prevalence Prevention Preventive Intervention Procedures Psychopathology Questionnaires Reporting Research Research Domain Criteria Research Proposals Rest Risk Sampling Schizophrenia Science Series Structure Technology Testing Time Toddler United States National Institutes of Health aged attentional bias behavioral construct behavioral impairment brain behavior clinically relevant connectome design flexibility infancy innovation neural circuit neuroimaging novel postnatal relating to nervous system social social communication symptomatology time interval vigilance

项目摘要

DESCRIPTION (provided by applicant): Infant Brain and Behavioral Signatures of Later Emerging Risk for Psychopathology Little is known about the trajectories of brain and behavioral development during infancy that anticipate and predict clinically impairing patterns of functioning observed during the preschool years. The prevalence of psychiatric symptomatology in preschool-aged children, combined with the possibility of common initializing pathophysiological events shared across various disorders, converge to highlight the infant and toddler period as uniquely suited for identifying atypical trajectories of brain and behavioral development that anticipate later emerging psychopathology. Characterizing trajectories that deviate from normative patterns of development during this time period may elucidate causal mechanisms of mental illness, mechanisms that subsequently could be targeted for strategic intervention/prevention. The proposed research will combine state-of-the-art neuroimaging technologies developed by the Human Connectome Project with a developmental approach to the NIMH Research Domain Criteria initiative. Longitudinal brain imaging (sMRI/DWI/fcMRI) and behavioral assessment (selected for relevance to later emerging psychopathology and acquired via direct assessment, parent report, and state-of-the art eye tracking procedures) will be conducted on 4 occasions between 3 and 15 months with a 5th assessment at 24 months of age. Dimensional aspects of clinically relevant behaviors will be characterized during a final 6th assessment between 30 and 36 months of age. The contribution of the proposed research is expected to be a comprehensive characterization of longitudinal brain development in the first years of life, coupled with a longitudinal characterization of behavioral constructs selected for their relevance to later emerging psychopathology. This contribution will be significant because the empirical data acquired will anchor a new paradigm of inquiry into the developmental processes that temporally precede the emergence of clinically impairing patterns of functioning, augmenting future efforts focused on strategic prevention of mental illness. The interdisciplinary synthesis that approaches clinical neuroscience or biological psychiatry from a developmental perspective represents an innovative departure from efforts designed to characterize neural signatures of DSM defined disorders examined years after the incipient pathophysiological events. More specifically, mapping trajectories of neural circuit development to behavioral constructs specifically selected for their relevance to later emerging psychopathology (Elison et al., 2013a; Elison et al., 2013b) highlights a novel developmental approach to the RDoC initiative. Indeed, these mappings will be characterized prior to the manifestation of clinically impairing patterns of functioning, and will be used to predict later emerging clinically relevant behaviors. Characterizing developmental signatures of later emerging psychopathology has the potential to alter the landscape of early identification and early intervention/prevention of psychiatric and neurodevelopmental disorders.

描述（由申请人提供）：婴儿的大脑和后来出现的心理病理风险的行为签名知之甚少在学前班时观察到。学龄前儿童精神症状学的流行，再加上共有各种疾病的病理生理事件的常见初始化的病理生理事件的可能性，融合以突出婴儿和幼儿时期，非常适合识别脑部和行为发展的轨迹，并预测后来的精神病学。表征在此期间偏离发展规范模式的轨迹可能阐明了精神疾病的因果机制，这些机制随后可能被用于战略干预/预防。拟议的研究将结合由人类Connectome项目开发的最新神经影像学技术与NIMH研究领域标准计划的发展方法。纵向大脑成像（SMRI/DWI/FCMRI）和行为评估（选择与后来的新兴心理病理学相关，并通过直接评估，父母报告和最新的ART眼动跟踪程序获取），将在3至15个月之间进行4次进行，并在24个月的时间为24个月的第5个月评估。在30到36个月大的最终第六次评估中，将对临床相关行为的维度方面进行表征。拟议研究的贡献预计将是生命初期纵向大脑发育的全面表征，再加上对行为构建的纵向表征，以与后来的新兴精神病理学相关。这项贡献将是重要的，因为所获得的经验数据将把新的探究范式纳入发展过程中，该过程从临床上造成的功能障碍模式的出现之前，扩大了未来的努力，以预防精神疾病的战略性预防。从发育的角度来看，跨学科的综合方法是从发育的角度使用临床神经科学或生物精神病学，这是一种创新的出现，而不是旨在表征DSM的神经特征的努力，而DSM定义的疾病已在初期的病理生理事件后几年所检查的疾病。更具体地说，将神经回路发展的轨迹映射到专门针对其与后来的新兴心理病理学相关性的行为结构（Elison等，2013a; Elison等，2013b）强调了RDOC计划的一种新型发展方法。实际上，这些映射将在临床上受损的功能模式表现之前进行表征，并将用于预测后来的新兴临床相关行为。表征后来新兴的心理病理学的发育特征有可能改变早期鉴定以及早期干预/预防精神病和神经发育障碍的景观。