Integrated study on mechanism of development and disorder of masticatory and swallowing function and visualization of neural circuits

咀嚼吞咽功能发育及紊乱机制及神经回路可视化综合研究

• 批准号: 21390549
• 负责人: YOSHIDA Noriaki
• 金额: $ 11.65万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390549/
• 关键词: 咀嚼; 嚥下; 発達; 障害; 咀嚼中枢; 咀嚼機能; 嚥下機能; ノックアウトマウス; 顎運動; 筋電図; 神経機構; 顎口腔機能

A process of development of masticatory and swallowing function was elucidated. As a result, it was suggested that the critical period of development of those functions was beyond 6 weeks of age in mice. Regarding the mechanism of disorder of masticatory and swallowing function, the formation of an abnormal central pattern generator is unlikely to occur. Such a disturbance may be produced at the site inferior to the central pattern generator. The obtained results indicated that neural circuits controlling jaw and tongue movements have a mutual interaction.

阐明了咀嚼和吞咽功能的发育过程。结果表明，小鼠这些功能发育的关键期超过6周龄。关于咀嚼和吞咽功能障碍的机制，不太可能发生异常中枢模式发生器的形成。这种干扰可能在中央图案发生器下方的位置产生。获得的结果表明控制下巴和舌头运动的神经回路具有相互作用。

项目成果

IFN-γ directly inhibits TNF-α-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/Fas ligand interactions

IFN-γ 在体外和体内直接抑制 TNF-α 诱导的破骨细胞生成，并诱导 Fas/Fas 配体相互作用介导的细胞凋亡

• 发表时间: 2011
• 影响因子: 4.4
• 作者: Haruka Kohara

The effects of fluoride intake on orthodontic tooth movement and on orthodontically induced root resorption

氟化物摄入量对正畸牙齿移动和正畸引起的牙根吸收的影响

• 发表时间: 2011
• 作者: Carmen Gonzales

IL-12 inhibits TNF-αinduced osteoclastogenesis via a T cell-independent mechanism in vivo

IL-12 通过体内 T 细胞独立机制抑制 TNF-α 诱导的破骨细胞生成

• 发表时间: 2009
• 影响因子: 4.1
• 作者: Yoshimatsu M; Kitaura H; Fujimura Y; Eguchi T; Kohara H; Morita Y; Yoshida N
• 通讯作者: Yoshida N

Effects of steroidal and nonsteroidal drugs on tooth movement and root resorption in the rat molar

甾体和非甾体药物对大鼠磨牙牙齿移动和牙根吸收的影响

• 发表时间: 2009
• 影响因子: 3.4
• 作者: Gonzales C; Hotokezaka H; Matsuo K; Shibazaki T; Yozgatian JH; Drrendeliler MA; Yoshida N
• 通讯作者: Yoshida N

交叉咬合モデルマウスを用いた顎口腔領域における形態変化と機能発達の関連性の解明

使用反咬合模型小鼠阐明口颌区域形态变化与功能发育之间的关系

• 发表时间: 2011
• 作者: 中村文