Elucidation of the mechanisms underlying podocyte injury through endoplasmic reticulum stress and Development of novel therapeutic strategies for glomerular diseases

阐明内质网应激导致足细胞损伤的机制并开发肾小球疾病的新治疗策略

• 批准号: 21591020
• 负责人: WADA Takehiko
• 金额: $ 2.91万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591020/
• 关键词: 腎臓学; 糸球体足細胞; 小胞体ストレス; 蛋白尿; アポトーシス; 分子シャペロン; 低酸素; グルコース; 虚血再灌流モデル

We investigated the implication of endoplasmic reticulum(ER) stress in the process of podocyte injury. Cultured growth-restrictive podocytes showed enhanced unfolded protein response under hypoxia, one of the metabolic stresses we tested. The apoptosis pathway associated with CHOP, which is one of the ER stress-related molecules, included a complicated network with Bcl-2-related proteins. Furthermore, we found that methylglyoxal, a carbonyl compound, directly damaged podocytes. Those results suggest that hypoxia, ER stress and carbonyl stress may have a crosstalk with each other and promote podocyte injury.

我们研究了内质网（ER）应激在足细胞损伤过程中的意义。培养的生长限制性足细胞在缺氧（我们测试的代谢应激之一）下表现出增强的未折叠蛋白反应。与内质网应激相关分子之一 CHOP 相关的细胞凋亡途径包括与 Bcl-2 相关蛋白的复杂网络。此外，我们发现甲基乙二醛（一种羰基化合物）直接损伤足细胞。这些结果表明缺氧、内质网应激和羰基应激可能相互影响并促进足细胞损伤。

项目成果

The role of glyoxalase system in renal hypoxia

乙二醛酶系统在肾缺氧中的作用

• DOI: 10.1007/978-1-4419-1241-1_6
• 发表时间: 2010
• 作者: Inagi R; Kumagai T; Fujita T; Nangaku M
• 通讯作者: Nangaku M

Glomerular diseases : genetic causes and future therapeutics

肾小球疾病：遗传原因和未来治疗

• DOI: 10.1038/nrneph.2010.103
• 发表时间: 2010
• 作者: Chiang CK; Inagi R
• 通讯作者: Inagi R

Abnormal Oxygen Metabolism and Epigenetic changes in Diabetic Kidney Disease

糖尿病肾病的氧代谢异常和表观遗传变化

• 发表时间: 2012
• 作者: Nangaku M

Endoplasmic reticulum stress in diabetic kidney disease: adaptation and apoptosis after three UPR pathways

糖尿病肾病中的内质网应激：三种 UPR 途径后的适应和凋亡

• DOI: 10.1007/s10495-023-01858-w
• 发表时间: 2023-06-07
• 期刊: Apoptosis
• 影响因子: 7.2
• 作者: Ruijing Zhang;C. Bian;Jing Gao;Huiwen Ren
• 通讯作者: Huiwen Ren

Cytoglobin, a novelglobin, plays an anti-fibrotic role in the kidney

细胞珠蛋白是一种新型球蛋白，在肾脏中具有抗纤维化作用

• DOI: 10.1152/ajprenal.00145.2010
• 发表时间: 2010
• 作者: Mimura I; Nangaku M; Nishi H; Inagi R; Tanaka T; Fujita T
• 通讯作者: Fujita T