Enhanced ghrelin production and secretion and reduced expression of ghrelin receptor in rat stomach with delayed gastric emptying

胃排空延迟大鼠胃中生长素释放肽的产生和分泌增强以及生长素释放肽受体的表达减少

• 批准号: 20790506
• 负责人: IWASAKI Eisuke
• 金额: $ 2.75万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790506/
• 关键词: グレリン; 胃排出; GHS受容体; 胃運動; 肥満; 機能性デイスペプシア; 胃排出障害; カハール介在細胞; 迷走神経; 機能性ディスペプシア

Ghrelin is a gastrointestinal peptide that exerts distinct effects on the gastrointestinal motility through the vagus nerve and gastric excitatory neural plexus. We investigated the influence of gastric outlet obstruction caused by surgical manipulation on the dynamics of ghrelin, GHS receptor or the gastric neural network in rats. This study had provided the first evidence that production and secretion of gastric ghrelin was enhanced with down-regulation of GHS receptor in rats with gastric outlet obstuction. The elevation of plasma ghrelin levels in rats with gastric outlet obstruction may stimulate gastric motility through activation of cholinergic neurons and interstitial cells of Cajar. These findings suggest that deregulation of gastric emptying might stimulate the ghrelin dynamics and network of gastric cellular communications between nerves and smooth muscle cells.

生长素释放肽是一种胃肠肽，通过迷走神经和胃兴奋性神经丛对胃肠运动产生明显的影响。我们研究了手术操作引起的胃出口梗阻对大鼠胃饥饿素、GHS 受体或胃神经网络动态的影响。这项研究提供了第一个证据，表明胃出口梗阻大鼠中 GHS 受体的下调会增强胃 Ghrelin 的产生和分泌。胃出口梗阻大鼠血浆生长素释放肽水平升高可能通过激活胆碱能神经元和卡哈尔间质细胞刺激胃蠕动。这些发现表明，胃排空失调可能会刺激胃饥饿素动力学以及神经和平滑肌细胞之间的胃细胞通讯网络。

项目成果

Enhanced ghrelin production and secretion and reduced expression of ghrelin receptor in rat stomach with delayed gastric emptying

胃排空延迟大鼠胃中生长素释放肽的产生和分泌增强以及生长素释放肽受体的表达减少

• 发表时间: 2008
• 作者: Iwasaki E; Suzuki H; Masaoka T; Nishizawa T; Takahashi T; Tsugawa H; Saito Y; Suzuki S; Hosoda H; Kangawa K; Hibi T.
• 通讯作者: Hibi T.

Enhanced Ghrelin Secretion and Gastric Excitatory Neural Network in Rats with Gastric Outlet Obstruction

胃出口梗阻大鼠胃饥饿素分泌增强和胃兴奋神经网络

• 发表时间: 2009
• 作者: Iwasaki E; Suzuki H; et al.
• 通讯作者: et al.

Decreased levels of adiponectin in obese patients with gastroesophageal reflux evaluated by videoesophagography: possible relationship between gastroesophageal reflux and metabolic syndrome

通过视频食管造影评估肥胖胃食管反流患者脂联素水平下降：胃食管反流与代谢综合征之间的可能关系

• 发表时间: 2009
• 作者: Iwasaki E; Suzuki H; Sugino Y; Iida T; Nishizawa T; Masaoka T; Hosoda H; Kangawa K; Hibi T.
• 通讯作者: Hibi T.

胃排出遅延モデルにおけるグレリン動態

胃排空延迟模型中的 Ghrelin 动力学

• 发表时间: 2008
• 作者: 岩崎栄典;鈴木秀和;正岡建洋;鈴木祥子;高橋哲史;西澤俊宏;齋藤義正;菅井恵津子;細田洋司;寒川賢治;日比紀文
• 通讯作者: 日比紀文

Decreased levels of adiponectin in obese patients with gastroesophageal reflux evaluated by videoesophagography : possible relationship between gastroesophageal reflux and metabolic syndrome

通过视频食管造影评估肥胖胃食管反流患者脂联素水平下降：胃食管反流与代谢综合征之间的可能关系

• 发表时间: 2009
• 作者: Iwasaki E; Suzuki H; Sugino Y; Iida T; Nishizawa T; Masaoka T; Hosoda H; Kangawa K; Hibi T
• 通讯作者: Hibi T