Training Program in Environmental Toxicology

环境毒理学培训计划

• 批准号: 10418745
• 负责人: F PETER Guengerich
• 金额: $ 74.06万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1975
• 资助国家: 美国
• 起止时间: 1975-07-10 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10418745
• 关键词: Training Programs; environmental toxicology

Project Summary Funds are requested to support eight predoctoral (Ph.D. candidates) and six postdoctoral trainees in the Training Program in Environmental Toxicology, a long-standing research training program in molecular toxicology at Vanderbilt University. This interdisciplinary program provides research career training in molecular aspects of toxicology related to environmental health. Because the field is inherently interdisciplinary, research training in the program spans chemistry, biochemistry, chemical biology, structural biology, analytical technology, microphysiological systems, functional genomics, pathogen-host interactions, disease pathology, and exposure science. The faculty preceptors have appointments in the departments of Biochemistry, Biological Sciences, Biomedical Informatics, Chemistry, Medicine, Pathology, Microbiology & Immunology, Obstetrics & Gynecology, Pediatrics and Physics all of whom have trained doctoral students and postdoctoral fellows. Training is achieved through basic and specialized coursework, research rotations, dissertation research, and participation in seminars, journal clubs, and joint research meetings. A distinctive feature of the program is hands-on training on diverse technology platforms through a highly developed and open system of research facility cores at Vanderbilt. A fraction of our graduate students are recruited through specific departments, while most matriculate through one of two umbrella programs: the Interdisciplinary Graduate Program in Biomedical and Biological Sciences (IGP) or the Quantitative and Chemical Biology Program (QCB). The students then spend their first 9 months in a common core curriculum and do laboratory rotations. Graduate students are supported for the first year by these programs or departments. Students then are recruited into the Training Program in Environmental Toxicology from these first-year pools, and training program support begins in the second year. Both predoctoral and postdoctoral trainees are selected by the Training Program Executive Committee composed of the Director, Associate Director and the Internal Advisory Committee, with guidelines to ensure distribution of trainees and monitoring of progress. The list of preceptors includes 17 faculty with diverse research interests and substantively well support research programs with the average current year direct costs available being over $1 million per investigators. Major research areas represented by our faculty preceptors include (1) Xenobiotic metabolism, detoxication, and enzymology; (2) Oxidative stress and inflammation; (3) DNA damage, genome maintenance, and replication; (4) Translational toxicology; (5) Host-pathogen-environment interactions; (6) Systems biology and developmental toxicology; and newly represented this cycle (7) Organs-on-chips and microphysiological systems. Graduates from the program have been highly successful in academia, industry, and other professional settings and include leaders in the field.

项目摘要 要求资金支持八个前院（博士学位）和六名博士后学员 环境毒理学培训计划，这是一项长期研究的分子研究培训计划 范德比尔特大学的毒理学。该跨学科计划提供研究职业培训 在与环境健康有关的毒理学分子方面。因为该字段是天生的 跨学科，计划的研究培训跨越化学，生物化学，化学生物学，结构性 生物学，分析技术，微生物生理系统，功能基因组学，病原体宿主相互作用， 疾病病理学和暴露科学。教职员工在部门有约会 生物化学，生物科学，生物医学信息学，化学，医学，病理学，微生物学和 免疫学，产科和妇科，儿科和物理学都培训了博士生和 博士后研究员。培训是通过基本和专业的课程，研究轮换来实现的 论文研究，并参加研讨会，期刊俱乐部和联合研究会议。一个独特的 该计划的功能是通过高度发达和高度的技术平台上的动手培训 范德比尔特的开放研究机构核心系统。通过招募我们的一小部分研究生 特定部门，虽然大多数通过两个伞计划之一入学：跨学科 生物医学和生物科学研究生课程（IGP）或定量和化学生物学 程序（QCB）。然后，学生们在公共核心课程中花费了头9个月并进行实验室 旋转。这些计划或部门的第一年支持研究生。然后学生 从这些第一年的游泳池和培训中招募到环境毒理学培训计划 计划支持从第二年开始。托管前和博士后学员均由 培训计划执行委员会由主任，副主任和内部咨询组成 委员会，并提供确保学员分配和监视进步的指南。受体列表 包括17位具有多种研究兴趣的教职员工，并在基本上很好地支持研究计划 现年平均直接费用可用于每个调查人员超过100万美元。主要研究领域 由我们的教职员工代表的包括（1）异生物代谢，解毒和酶学； （2） 氧化应激和炎症； （3）DNA损伤，基因组维持和复制； （4）翻译 毒理学; （5）宿主 - 病原 - 环境相互作用； （6）系统生物学和发育毒理学； 并新代表了片上的器官和微生物生理系统（7）。毕业生 计划在学术界，行业和其他专业环境中取得了非常成功的成功，包括 该领域的领导者。