Influence of sleep apnea syndrome on clock gene dysfunction

睡眠呼吸暂停综合征对时钟基因功能障碍的影响

• 批准号: 20590923
• 负责人: BURIOKA Naoto
• 金额: $ 2.41万
• 依托单位: Tottori University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590923/
• 关键词: 睡眠時無呼吸症候群; 間歇的低酸素; 時計遺伝子; IL-6; VEGF; 内科学; 低酸素; 生理学

Obstructive sleep apnea syndrome (OSAS) clinically causes intermittent hypoxia (IH) during sleep. The levels of an inflammation cytokine interleukin-6 (IL-6) mRNA significantly elevated by IH condition in cultured human lung adenocarcinoma epithelial cells (A549), due to activation of the signaling pathway of nuclear factor-KB (NF-KB) which is a potent transcriptional activator of IL-6. However, the treatment of cells with IH had little effect on clock gene expressions. Serum concentrations of IL-6 in OSAS patients were significantly higher than in healthy subjects, but elevated levels of IL-6 in OSAS patients fell to the level of healthy subjects after CPAP therapy. The condition of IH can activate signal transduction to an inflammatory response, but not to circadian clock regulation. The increase of serum IL-6 may cause systemic inflammation in patients with OSAS.

阻塞性睡眠呼吸暂停综合征（OSAS）在临床上会导致睡眠期间间歇性缺氧（IH）。 IH 条件下培养的人肺腺癌上皮细胞 (A549) 中炎症细胞因子白细胞介素 6 (IL-6) mRNA 的水平显着升高，这是由于核因子 KB (NF-KB) 信号通路的激活所致。 IL-6 的有效转录激活剂。然而，用 IH 处理细胞对时钟基因表达几乎没有影响。 OSAS患者血清IL-6浓度显着高于健康受试者，但OSAS患者升高的IL-6水平在CPAP治疗后降至健康受试者水平。 IH 的情况可以激活炎症反应的信号转导，但不能激活生物钟调节。 OSAS患者血清IL-6升高可能引起全身炎症。

项目成果

Asthma : chronopharmacotherapy and the molecular clock.

哮喘：时间药物疗法和分子钟。

• 发表时间: 2010
• 作者: Burioka N; et al
• 通讯作者: et al

Influence of intermittent hypoxia on the signal transduction pathways to inflammatory response and circadian clock regulation.

间歇性缺氧对炎症反应和生物钟调节信号转导途径的影响。

• 发表时间: 2009
• 作者: Burioka N; Koyanagi S; et al
• 通讯作者: et al

Clock gene dysfunction in patients with obstructive sleep apnea syndrome

阻塞性睡眠呼吸暂停综合征患者的时钟基因功能障碍

• 发表时间: 2008
• 作者: Burioka N; et al.
• 通讯作者: et al.

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Asthma : chronopharmacotherapy and the molecular clock.

哮喘：时间药物疗法和分子钟。

• 发表时间: 2010
• 作者: Burioka N; Fukuoka Y; Koyanagi S; Miyata M; Takata M; Chikumi H; Watanabe M; Endo M; Sako T; Suyama H; Ohdo S; Shimizu E.
• 通讯作者: Shimizu E.