Development and clinical utility of membrane humidifier without need of water for humidification

无需水加湿的膜加湿器的研制及临床应用

• 批准号: 10670544
• 负责人: BURIOKA Naoto
• 金额: $ 0.96万
• 依托单位: Tottori University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670544/
• 关键词: humidifier; relative humidity; chronic respiratory failure; bacterial culture; bacterial contamination; oxygen concentration; hollow fiber

It is well known that conventional bubbling humidifiers are capable of producing micro-aerosols contaminated with bacteria. We developed a unique humidifier named as membrane humidifier that does not require an external water supply. This new system obtains moisture from room air. We investigated the clinical and in vitro evaluation of membrane humidifier.Ten patients with chronic pulmonary disease participated in the study. We evaluated the partial pressure of oxygen in arterial blood (PaOィイD22ィエD2) of 10 patients who used the new device. We conducted an in vitro study to determine whether the device could prevent the bacterial contamination of humidified-oxygen passed inside the hollow fibers was sampled into nutrient broth periodically for 10 days. We also compared the relative humidity of oxygen humidified by a membrane humidifier with that of oxygen humidified by a bubbling humidifier.There was no significant difference between measured PaOィイD22ィエD2 while breathing oxygen humidified using a membrane humidifier and that while breathing oxygen humidified using a bubbling humidifier. Cultures of the humidified-oxygen passed through the hollow fibers were negative for bacteria. The membrane humidifier could produce well humidification.The new device appeared to prevent bacterial contamination, and may help to reduce the risk of infection in patients at hospital and home.

众所周知，传统的鼓泡加湿器能够产生被细菌污染的微气溶胶，我们开发了一种独特的加湿器，称为膜加湿器，不需要外部供水，我们对室内空气进行了研究。以及膜加湿器的体外评估。我们评估了 10 名慢性肺部疾病患者的动脉血氧分压 (PaO D22 D2)。我们对新设备进行了一项体外研究，以确定该设备是否可以防止通过中空纤维内部的加湿氧气的细菌污染，我们还定期将加湿氧气取样到营养肉汤中，为期 10 天。膜加湿器加湿的氧气与鼓泡加湿器加湿的氧气的PaOiD22相比，膜加湿器加湿的呼吸氧气时测量的PaOiD22与呼吸氧气时的PaOiD22没有显着差异使用鼓泡加湿器加湿，通过中空纤维的加湿氧气培养物对细菌呈阴性。膜加湿器可以产生良好的加湿效果。新装置似乎可以防止细菌污染，并可能有助于降低患者感染的风险。在医院和家里。

项目成果

Naoto Burioka: "Membrane humidifier without need of external water for humidification" Respirology. 3・supple. A71 (1998)

Naoto Burioka：“无需外部水进行加湿的膜加湿器”呼吸学 3·supple (1998)。

Burioka N: "Membrane humidifier that does not require addition of water"Yonago Acta medica. 42. 185-188 (1999)

Burioka N：“不需要加水的膜加湿器”米子医学学报。

Burioka N: "Membrane humidifier without need of external water for humidification"Respirology. 3(supple). A71 (1998)

Burioka N：“无需外部水进行加湿的膜加湿器”呼吸学。

Burioka N: "Membrane humiditier that does not require addition of water"Yonago Acta medica. 42. 185-188 (1999)

Burioka N：“不需要加水的膜加湿器”米子医学学报。

Burioka N: "Clinical and in vitro evaluation of membrane humidifier that does not require addition of water"Respiratory Medicine. (in press). (2000)

Burioka N：“不需要加水的膜加湿器的临床和体外评估”呼吸医学。