Development of VHL-targeted therapy in malignant pleural mesothelioma

恶性胸膜间皮瘤VHL靶向治疗的进展

• 批准号: 15K06878
• 负责人: Koh Yasuhiro
• 金额: $ 3.24万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K06878/
• 关键词: 悪性胸膜中皮腫; VHL変異; がん個別化医療; 分子標的治療; HIF-1

项目成果

Development of an automated size-based filtration system for isolation of circulating tumor cells in lung cancer patients.

• DOI: 10.1371/journal.pone.0179744
• 发表时间: 2017
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Yagi S;Koh Y;Akamatsu H;Kanai K;Hayata A;Tokudome N;Akamatsu K;Endo K;Nakamura S;Higuchi M;Kanbara H;Nakanishi M;Ueda H;Yamamoto N
• 通讯作者: Yamamoto N

The efficacy of uracil DNA glycosylase pretreatment in amplicon-based massively parallel sequencing with DNA extracted from archived formalin-fixed paraffin-embedded esophageal cancer tissues

• DOI: 10.1016/j.cancergen.2015.05.001
• 发表时间: 2015-09-01
• 期刊: CANCER GENETICS
• 影响因子: 1.9
• 作者: Serizawa, Masakuni;Yokota, Tomoya;Koh, Yasuhiro
• 通讯作者: Koh, Yasuhiro

Comparative analysis of PD-L1 expression between circulating tumor cells and tumor tissues in patients with lung cancer

肺癌患者循环肿瘤细胞与肿瘤组织PD-L1表达量对比分析

• 发表时间: 2016
• 作者: Hayashi Hidetoshi;Chiba Yasutaka;Sakai Kazuko;Fujita Tomonobu;Yoshioka Hiroshige;Sakai Daisuke;Kitagawa Chiyoe;Naito Tateaki;Takeda Koji;Okamoto Isamu;Mitsudomi Tetsuya;Kawakami Yutaka;Nishio Kazuto;Nakamura Shinichiro;Yamamoto Nobuyuki;Nakagawa Kazuhiko;Nokihara H;Naito T;Naito T;Sato K;Tanaka A;Hayata A;Kikuchi T;Schuler M;Sekine I;Azuma K;Nosaki K;Goto K;Yoh K;Atagi S;Hiroaki Akamatsu;Makoto Nishio;James Yang;Takehito Shukuya;Murakami Hiroyasu;Akamatsu H;Kambayashi S;Koh Y;Shibaki R;Otsubo K;Takiguchi Y;Yamamoto N;Yamamoto N;Sato K;Shibaki R;Akamatsu H;Oyanagi J;Koh Y,
• 通讯作者: Koh Y,

Predictive impact of PD-L1-expressing circulating tumor cells in NSCLC patients treated with nivolumab.

表达 PD-L1 的循环肿瘤细胞对接受纳武单抗治疗的 NSCLC 患者的预测影响。

• 发表时间: 2017
• 作者: Hayashi Hidetoshi;Chiba Yasutaka;Sakai Kazuko;Fujita Tomonobu;Yoshioka Hiroshige;Sakai Daisuke;Kitagawa Chiyoe;Naito Tateaki;Takeda Koji;Okamoto Isamu;Mitsudomi Tetsuya;Kawakami Yutaka;Nishio Kazuto;Nakamura Shinichiro;Yamamoto Nobuyuki;Nakagawa Kazuhiko;Nokihara H;Naito T;Naito T;Sato K;Tanaka A;Hayata A;Kikuchi T;Schuler M;Sekine I;Azuma K;Nosaki K;Goto K;Yoh K;Atagi S;Hiroaki Akamatsu;Makoto Nishio;James Yang;Takehito Shukuya;Murakami Hiroyasu;Akamatsu H;Kambayashi S;Koh Y;Shibaki R
• 通讯作者: Shibaki R

Comparison of PD-L1 expression between tumor tissues and circulating tumor cells and tumor tissues in patients with lung cancer

肺癌患者肿瘤组织与循环肿瘤细胞及肿瘤组织中PD-L1表达量比较

• 发表时间: 2016
• 作者: Hayashi Hidetoshi;Chiba Yasutaka;Sakai Kazuko;Fujita Tomonobu;Yoshioka Hiroshige;Sakai Daisuke;Kitagawa Chiyoe;Naito Tateaki;Takeda Koji;Okamoto Isamu;Mitsudomi Tetsuya;Kawakami Yutaka;Nishio Kazuto;Nakamura Shinichiro;Yamamoto Nobuyuki;Nakagawa Kazuhiko;Nokihara H;Naito T;Naito T;Sato K;Tanaka A;Hayata A;Kikuchi T;Schuler M;Sekine I;Azuma K;Nosaki K;Goto K;Yoh K;Atagi S;Hiroaki Akamatsu;Makoto Nishio;James Yang;Takehito Shukuya;Murakami Hiroyasu;Akamatsu H;Kambayashi S;Koh Y;Shibaki R;Otsubo K;Takiguchi Y;Yamamoto N;Yamamoto N;Sato K;Shibaki R;Akamatsu H;Oyanagi J;Koh Y,;Hayakawa K;Kim Y;Koh Y
• 通讯作者: Koh Y