A study of the effect of a recombinant immunosuppressive factor from parasites and immune-inhibitory mechanisms

重组寄生虫免疫抑制因子的作用及免疫抑制机制研究

• 批准号: 21590464
• 负责人: FUKUMOTO Soji
• 金额: $ 3万
• 依托单位: Tottori University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590464/
• 关键词: 寄生虫; マンソン裂頭条虫; 免疫抑制因子; マクロファージ; 旋毛虫; 遺伝子発; peroxiredoxin; 腹腔マクロファージ; alternative activation; 遺伝子組換えタンパク質; cDNA; RACE法; 遺伝子組み換えタンパク; 腹腔マクロフージ; プレロセルコイド; 遺伝子発現抑制; クローニング

An immunosuppressive factor(ES90) from Spirometra erinaceieuropaei plerocercoids was cloned and the recombinant ES90 was synthesized using wheat germ cell free expression system. However, the recombinant ES90 did not inhibit nitric oxide production in macrophages. Messenger RNA of Ym1, FIZZ1, and arginase 1 were expressed in peritoneal macrophages from Trichinella spiralis-infected mice. In connection with this, 2 types of peroxiredoxin(Prx) from T. spiralis were cloned, Prx-1 mRNA expression was stage-specific

克隆了来自erinaceieuropaei plerocercoids的免疫抑制因子（ES90），并利用小麦胚芽细胞自由表达系统合成了重组ES90。然而，重组ES90并不抑制巨噬细胞中一氧化氮的产生。 Ym1、FIZZ1 和精氨酸酶 1 的信使 RNA 在旋毛虫感染小鼠的腹膜巨噬细胞中表达。与此相关，从旋毛虫中克隆了两种类型的过氧化还原蛋白（Prx），Prx-1 mRNA 表达具有阶段特异性

项目成果

Neural Network with Unbounded Activation Functions is Universal Approximator

• DOI: 10.1016/j.acha.2015.12.005
• 发表时间: 2015-05-14
• 期刊: arXiv: Neural and Evolutionary Computing
• 作者: Sho Sonoda;Noboru Murata
• 通讯作者: Noboru Murata