Genetic Association Study on HLA with Interstitial Lung Diseases in Rheumatoid Arthritis Patients.

类风湿性关节炎患者 HLA 与间质性肺疾病的遗传关联研究。

• 批准号: 24791018
• 负责人: HASHIMOTO Atsushi
• 金额: $ 2.75万
• 依托单位: Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791018/
• 关键词: 関節リウマチ; 間質性肺病変; HLA; 遺伝子解析

Interstitial lung disease is a critical complication associated with rheumatoid arthritis (RA). Methotrexate-induced interstitial lung disease (MI-ILD) can occur in RA patients and represents a potentially life-threatening drug hypersensitivity reaction. It is believed that Japanese RA patients are more susceptible to MI-ILD than other ethnic groups. Striking association of human leukocyte antigen (HLA) class I alleles with severe cutaneous adverse reactions has recently been reported for many drugs. Here, we investigated the association of HLA with ILD in RA. HLA-DRB1*04, shared epitope (SE) and DQB1*04 were associated with significantly decreased risk of ILD. In contrast, DRB1*16, DR2 serological group and DQB1*06 were significantly associated with risk of ILD. We found a highly significant association of the A*31:01 allele with MI-ILD.

间质肺疾病是与类风湿关节炎（RA）相关的关键并发症。 RA患者可能发生甲氨蝶呤诱导的间质肺疾病（MI-ILD），代表潜在的威胁生命的药物超敏反应。据信，日本RA患者比其他种族更容易受到MI-sil的影响。最近，许多药物的人类白细胞抗原（HLA）I类具有严重皮肤不良反应的I类等位基因的惊人关联。在这里，我们研究了HLA与RA中的ILD的关联。 HLA-DRB1*04，共享表位（SE）和DQB1*04与ILD风险显着降低有关。相反，DRB1*16，DR2血清学组和DQB1*06与ILD风险显着相关。我们发现A*31：01等位基因与Mi-ild有着非常重要的关联。

项目成果

RAに伴う間質性肺病変とHLAとの関連

RA与HLA相关肺间质病变的关系

• 发表时间: 2012
• 作者: Kiyonori Tanoue;Yuqing Wang;Takao Setoguchi;Setsuro Komiya;Shoji Natusgoe;Ken-ichiro Kosai.;古川宏ほか
• 通讯作者: 古川宏ほか

A case of granulomatosis with polyangiitis (Wegener's granulomatosis) manifested with asymptomatic intracerebral hemorrhage

• DOI: 10.2177/jsci.36.58
• 发表时间: 2013-02
• 期刊: Japanese Journal of Clinical Immunology
• 作者: H. Takaoka;A. Hashimoto;S. Nogi;K. Iwata;H. Futami;Y. Arinuma;K. Shimada;H. Nakayama;A. Komiya;H. Furukawa;T. Matsui;S. Tohma

BEING UNDERWEIGHT IS ASSOCIATED WITH HIGH DISEASE ACTIVITY AND INCREASED RISK FOR HOSPITALIZATION IN PATIENTS WITH RHEUMATOID ARTHRITIS

体重过轻与类风湿性关节炎患者的高疾病活动度和住院风险增加相关

• 发表时间: 2012
• 作者: Matsui T;Nishino J;Kuga Y;Tsuno H;Hashimoto A;Tohma S
• 通讯作者: Tohma S

Genome, epigenome and transcriptome analyses of a pair of monozygotic twins discordant for systemic lupus erythematosus

• DOI: 10.1016/j.humimm.2012.11.007
• 发表时间: 2013-02-01
• 期刊: HUMAN IMMUNOLOGY
• 影响因子: 2.7
• 作者: Furukawa, Hiroshi;Oka, Shomi;Tohma, Shigeto
• 通讯作者: Tohma, Shigeto

Association of a single nucleotide polymorphism in the SH2D1A intronic region with systemic lupus erythematosus

• DOI: 10.1177/0961203313479421
• 发表时间: 2013-04-01
• 期刊: LUPUS
• 影响因子: 2.6
• 作者: Furukawa, H.;Kawasaki, A.;Tohma, S.
• 通讯作者: Tohma, S.