Proposal and verification the hypothesis "coagulation,IFNγ andPAI-1 control liver fibrosis and carcinogenesis mechanism"

“凝血、IFNγ和PAI-1控制肝纤维化和癌变机制”假说的提出和验证

• 批准号: 23659660
• 负责人: FUJIMOTO Jiro
• 金额: $ 2.33万
• 依托单位: Hyogo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659660/
• 关键词: 肝線維化; IFN-γ; PAI-1; tPA; 国際情報交換（米国）; 国際情報交流

We elucidated that blood coagulation system and IFN-γ(Interferon-gamma), PAI-1(Plasminogen activator inhibitor-1) controlled the adhesion, desmoplasia by operation adhesion mechanism analysis. From this analysis, we hypothesized that blood coagulation system, IFN-γ, PAI-1 played an important role in liver fibrosis and inspected it by the PAI-1 knockout mice, and it was suggested that PAI-1 and t-PA （tissue plasminogen activator) affected liver fibrosis but IFN-γ did not contribute so much using a mouse model that was ligated bile duct.

通过手术粘连机制分析，我们阐明了凝血系统和IFN-γ（干扰素-γ）、PAI-1（纤溶酶原激活剂抑制剂-1）控制粘连、结缔组织形成，由此我们进化出凝血系统、IFN-。 γ、PAI-1在肝纤维化中发挥重要作用，并通过PAI-1敲除小鼠进行了检测，提示PAI-1和t-PA（组织纤溶酶原激活剂）对肝纤维化有影响，但在结扎胆管的小鼠模型中，IFN-γ 的贡献并不大。