Analysis of molecular mechanism and the regulation of adhesion
分子机制分析及粘附调控
基本信息
- 批准号:22390250
- 负责人:
- 金额:$ 12.15万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2010
- 资助国家:日本
- 起止时间:2010 至 2012
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We analyzed the adhesion formation after hepatectomy in mice and humans. After hepatectomy, NKT cells in the liver accumulated nearby cut end and produced IFN-γ. Hepatocyte produced PAI-1, fibrinolysis factor, dependent on IFN-γproduction. These molecules are crucial role for adhesion formation after hepatectomy. Mice treated with recombinant HGF was decreased adhesion formation after hepatectomy though inhibition both IFN-γand PAI-1 production. This treatment may apply for the adhesions in human cases in near future.
我们分析了小鼠和人类肝切除后的粘附形成。肝切除后,肝脏中的 NKT 细胞在切口附近聚集并产生 IFN-γ。肝细胞产生 PAI-1(纤维蛋白溶解因子),这些分子至关重要。肝切除术后粘连形成的作用虽然IFN-γ和PAI-1的产生可能适用于重组HGF治疗的小鼠,但肝切除抑制后粘连形成减少。在不久的将来,人类病例中会出现粘连。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Hepatocyte growth factor inhibited adhesion formation after hepatectomy by regulating interferon-gamma and plasminogen activator inhibitor-1 in mice
肝细胞生长因子通过调节干扰素-γ和纤溶酶原激活剂抑制剂-1抑制小鼠肝切除术后粘连形成
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:大橋浩一郎;藤元治朗;ほか;根岸淳;大橋浩一郎
- 通讯作者:大橋浩一郎
Hepatocyte growth factor prevented abdominal adhesion formation after hepatectomy by regulating interferon-γ and plasminogen activator inhibitor-1
肝细胞生长因子通过调节干扰素-γ和纤溶酶原激活剂抑制剂-1预防肝切除术后腹腔粘连形成
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:大橋浩一郎;藤元治朗;ほか
- 通讯作者:ほか
IFN-γ derived from NKT cells and plasminogen activator inhibitor-1 (PAI-1) regulate adhesion formation after hepatectomy
NKT 细胞衍生的 IFN-γ 和纤溶酶原激活剂抑制剂-1 (PAI-1) 调节肝切除术后粘附形成
- DOI:
- 发表时间:2012
- 期刊:
- 影响因子:0
- 作者:犬伏 正幸;他;南本亮吾;大橋 浩一郎
- 通讯作者:大橋 浩一郎
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FUJIMOTO Jiro其他文献
FUJIMOTO Jiro的其他文献
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{{ truncateString('FUJIMOTO Jiro', 18)}}的其他基金
Proposal and verification the hypothesis "coagulation,IFNγ andPAI-1 control liver fibrosis and carcinogenesis mechanism"
“凝血、IFNγ和PAI-1控制肝纤维化和癌变机制”假说的提出和验证
- 批准号:
23659660 - 财政年份:2011
- 资助金额:
$ 12.15万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Establishment of experimental surgical adhesion model and analysis of immunological mechanism underlying organ adhesion
实验性手术粘连模型的建立及器官粘连免疫机制分析
- 批准号:
19390342 - 财政年份:2007
- 资助金额:
$ 12.15万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Analysis of the role of angiogenesis and non-parenchymal cells during hepatic regeneration.
分析血管生成和非实质细胞在肝再生过程中的作用。
- 批准号:
17390375 - 财政年份:2005
- 资助金额:
$ 12.15万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Angiogenesis and tumor dormancy therapy in gynecological cancer
妇科癌症的血管生成和肿瘤休眠治疗
- 批准号:
14370528 - 财政年份:2002
- 资助金额:
$ 12.15万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Basic research and clinical approach of molecular therapy for liver cirrhosis and HCC
肝硬化和肝癌分子治疗的基础研究和临床途径
- 批准号:
14370395 - 财政年份:2002
- 资助金额:
$ 12.15万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Functional analysis of LATS protein kinases, products of novel tumor-suppressor genes
新型抑癌基因产物 LATS 蛋白激酶的功能分析
- 批准号:
12670130 - 财政年份:2000
- 资助金额:
$ 12.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
GENE THERAPY OF LIVER CIRRHOSIS ; BASIC RESEARCH AND A PROSPECT FOR CLINICAL TRIAL
肝硬化的基因治疗;
- 批准号:
11470266 - 财政年份:1999
- 资助金额:
$ 12.15万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Angiogenesis in female genital tract cancers and its inhibition
女性生殖道癌症的血管生成及其抑制
- 批准号:
11671606 - 财政年份:1999
- 资助金额:
$ 12.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Functional analysis of FAK tyrosine kinase in intracellular signaling pathways
FAK酪氨酸激酶在细胞内信号通路中的功能分析
- 批准号:
09680668 - 财政年份:1997
- 资助金额:
$ 12.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Study of endocrinological contribution for invasion and metastasis in gynecological cancers
内分泌对妇科癌症侵袭和转移的贡献研究
- 批准号:
08671881 - 财政年份:1996
- 资助金额:
$ 12.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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