Qualitative improvement of aged eggs and development of technologies supporting ART at later ages

老化卵子的质的提高和后期辅助ART技术的开发

• 批准号: 23659107
• 负责人: KURIHARA Hiroki
• 金额: $ 2.41万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659107/
• 关键词: 生殖医学; 老化; 卵子; 体外受精; ミトコンドリア; サーチュイン遺伝子; 初期発生

Changes in women’s life styles have lead to the tendency of late childbearing, requiring ART at later ages. However, oxidative stress and decreased mitochondrial function are supposed to cause the deterioration of eggs with increasing age. In this study, we found that mitochondrial NAD+-dependent deacetylase Sirt3 may be involved in mechanisms underlying the deterioration and introduction of Sirt3 may improve the post-fertilization development. Furthermore, we established transgenic mice conditionally expressing Sirt3 in specific cell types including oocytes and eggs, whose phenotype is being analyzed.

妇女的变化导致了晚期生育的趋势，需要以后的艺术年龄。 SIRT3的变质和引入可能会改善后有限的DEE Velopment。我们建立了在包括特定细胞类型的特定细胞类型和鸡蛋中表达SIRT3的转基因小鼠。

项目成果

The novel contribution of preotic neural crest cells in the coronary artery development

前神经嵴细胞在冠状动脉发育中的新贡献

• 发表时间: 2012
• 作者: Kusumoto;B.;et al.;有馬勇一郎;有馬勇一郎
• 通讯作者: 有馬勇一郎

Collectiveendothelial cell movement in angiogenic morphogenesis

血管生成形态发生中的集体内皮细胞运动

• 发表时间: 2011
• 作者: 深谷昌弘;原芳伸;阪上洋行;陳和夫;Egawa,R.,Hososhima,S.,Ishizuka,T.,Nakamura,H.,andYawo,H;Koichi Nishiyama
• 通讯作者: Koichi Nishiyama

Endothelin-1/Endothelin type-A receptor signaling regulates pharyngeal arch artery development through Dlx5/6-independent pathway

内皮素1/内皮素A型受体信号通过Dlx5/6独立途径调节咽弓动脉发育

• 发表时间: 2011
• 作者: 片村嘉男;相方浩;長沖祐子;石田友希;橋本義政;河岡友和;高木慎太郎;脇浩司;平松憲;高橋祥一;茶山一彰;山下潤;前村浩二;Ki-Sung Kim
• 通讯作者: Ki-Sung Kim

Imaging, quantification and modeling of self-organizing behaviors of vascular cells

血管细胞自组织行为的成像、量化和建模

• 发表时间: 2012
• 作者: Yokoi K;Sumitsuji S;Kaneda H;Siegrist P;Okayama K;Ide S;Mizote I;Kumada M;Kuroda T;Tachibana K;Sakata Y;Nanto S;西山功一
• 通讯作者: 西山功一

Mechanism involving dynamic and heterogeneous endothelial cell movement during angiogenesis

血管生成过程中涉及动态和异质内皮细胞运动的机制

• 发表时间: 2011
• 作者: Nishiyama K