Identification of novel cell lineages contributing to cardiovascular development and clarification of mechanisms underlying their fate determination

鉴定有助于心血管发育的新细胞谱系并阐明其命运决定的机制

基本信息

  • 批准号:
    21390238
  • 负责人:
  • 金额:
    $ 11.65万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 财政年份:
    2009
  • 资助国家:
    日本
  • 起止时间:
    2009 至 2011
  • 项目状态:
    已结题

项目摘要

Early endothelin receptor type A expression defines a subdomain of the first heart field contributing to chamber formation, in which endothelin signaling is involved by stimulating ERK phosphorylation and Tbx5 expression. In angiogenesis, complex cell behavior and tip cell overtaking were revealed to contribute to branching morphogenesis by a time-lapse imaging and computer-assisted analysis.
早期内皮素受体A型表达表达定义了第一个心脏场的子域,导致腔室形成,其中内皮素信号传导刺激ERK磷酸化和TBX5表达涉及。在血管生成中,揭示了复杂的细胞行为和超过的尖端细胞超过,从而通过延时成像和计算机辅助分析有助于分支形态发生。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass
  • DOI:
    10.1016/j.devcel.2009.02.003
  • 发表时间:
    2009-03-17
  • 期刊:
  • 影响因子:
    11.8
  • 作者:
    Nishioka, Noriyuki;Inoue, Ken-ichi;Sasaki, Hiroshi
  • 通讯作者:
    Sasaki, Hiroshi
Effects of topical application of alpha-D-glucosylglycerol on dermal levels of insulin-like growth factor-I in mice and on facial skin elasticity in humans
局部应用 α-D-葡萄糖基甘油对小鼠真皮胰岛素样生长因子-I 水平和人类面部皮肤弹性的影响
  • DOI:
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Kurotani R;Okumura S;Matsubara T;Yokoyama U;Buckley JR;Tomita T;Kezuka K;Nagano T;Esposito D;Taylor TE;Gillette WK;Ishikawa Y;Abe H;Ward JM;and Kimura S;Harada N
  • 通讯作者:
    Harada N
Evolving maps in craniofacial development. Semin
颅面发育的演变图。
  • DOI:
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ago T;et al.;Gitton Y
  • 通讯作者:
    Gitton Y
Involvement of non-coding RNA in the Endotelin signaling in branchial arch development
非编码 RNA 参与鳃弓发育的内皮素信号传导
  • DOI:
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Yano Y;Inokuchi T;Kario K.;Yukiko Kurihara
  • 通讯作者:
    Yukiko Kurihara
Transcriptional regulation of non-coding RNA Evf-2 in the Endothelin-1/Dlx5/Dlx6 pathway
Endothelin-1/Dlx5/Dlx6 通路中非编码 RNA Evf-2 的转录调控
  • DOI:
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Y Matsumoto;他;Yasunobu Uchijima
  • 通讯作者:
    Yasunobu Uchijima
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

KURIHARA Hiroki其他文献

KURIHARA Hiroki的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('KURIHARA Hiroki', 18)}}的其他基金

Characterization of neural crest cells migrating into the heart
神经嵴细胞迁移到心脏的特征
  • 批准号:
    26670396
  • 财政年份:
    2014
  • 资助金额:
    $ 11.65万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Establishment of the concept of broad organ-forming network in cardiovascular formation and models for tissue reconstruction
心血管形成中广泛器官形成网络概念的建立和组织重建模型
  • 批准号:
    24249047
  • 财政年份:
    2012
  • 资助金额:
    $ 11.65万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Qualitative improvement of aged eggs and development of technologies supporting ART at later ages
老化卵子的质的提高和后期辅助ART技术的开发
  • 批准号:
    23659107
  • 财政年份:
    2011
  • 资助金额:
    $ 11.65万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Analysis of cardiovascular development and pathophysiology by gene engineering of the endothelin system in mice
通过内皮素系统基因工程分析小鼠心血管发育和病理生理学
  • 批准号:
    18390229
  • 财政年份:
    2006
  • 资助金额:
    $ 11.65万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Molecular cascades underlying the integration of cell differentiation and morphogenesis in cranial/cardiac neural crest development
颅/心脏神经嵴发育中细胞分化和形态发生整合的分子级联
  • 批准号:
    16390218
  • 财政年份:
    2004
  • 资助金额:
    $ 11.65万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Molecular signaling mechanisms underlying cardiovascular and branchial morphogenesis
心血管和鳃形态发生的分子信号机制
  • 批准号:
    14370231
  • 财政年份:
    2002
  • 资助金额:
    $ 11.65万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
ESTABLISHMENT OF MICE DEFICTENT IN A VASOACTIVE PEPTIDE BY GENE TARGETING AND THEIR APPLICATION TO PATHOPHYSIOLOGICAL ANALYSIS
通过基因打靶建立血管活性肽缺陷小鼠及其在病理生理学分析中的应用
  • 批准号:
    06454286
  • 财政年份:
    1994
  • 资助金额:
    $ 11.65万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
ESTABLISHMENT OF AN ANIMAL MODEL FOR CONGENITAL CRANIOFACIAL DISEASES BY GENE TARGETING AND DEVELOPMENT OF THEIR GENETIC DIAGNOSIS.
通过基因打靶建立先天性颅面疾病动物模型并开发其遗传诊断。
  • 批准号:
    06557065
  • 财政年份:
    1994
  • 资助金额:
    $ 11.65万
  • 项目类别:
    Grant-in-Aid for Developmental Scientific Research (B)

相似海外基金

分岐解析によるヒト心筋細胞モデルデータベース構築と心臓自動能発生機序の統合的解明
利用分叉分析构建人体心肌细胞模型数据库并综合阐明心脏自动功能生成机制
  • 批准号:
    22K06850
  • 财政年份:
    2022
  • 资助金额:
    $ 11.65万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
iPS細胞由来心筋exosomeを用いた新規cell-free心臓再生療法の開発
使用 iPS 细胞来源的心肌外泌体开发新型无细胞心脏再生疗法
  • 批准号:
    21K19528
  • 财政年份:
    2021
  • 资助金额:
    $ 11.65万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
Elucidation of the mechanism of genotype-phenotype correlation in cardiomyopathy using disease-specific isogenic iPS cells
使用疾病特异性同基因 iPS 细胞阐明心肌病基因型-表型相关性的机制
  • 批准号:
    20K08193
  • 财政年份:
    2020
  • 资助金额:
    $ 11.65万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Comprehensive Platform for Studying Molecular Mechanisms Regulating Cardiomyocyte Maturation
心肌细胞成熟调控分子机制研究综合平台
  • 批准号:
    19KK0219
  • 财政年份:
    2019
  • 资助金额:
    $ 11.65万
  • 项目类别:
    Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
Molecular mechanisms of cell differentiation during development of great vessels and ventricles
大血管和心室发育过程中细胞分化的分子机制
  • 批准号:
    19H03398
  • 财政年份:
    2019
  • 资助金额:
    $ 11.65万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了