Analysis of neuroprotective function of Parkinson's Disease Gene DJ-1

帕金森病基因DJ-1的神经保护功能分析

• 批准号: 23790970
• 负责人: TAKAHASHI-NIKI Kazuko
• 金额: $ 2.75万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790970/
• 关键词: DJ-1; パーキンソン病; PARK7; 酸化ストレス; 分泌

[Function analysis of DJ-1 secreted under oxidative stress] We found that secreted DJ-1 from astrocytes protected co-cultured neurons against oxidative stress. Furthermore, we found that the amount of secreted DJ-1 mutants found in Familial Parkinson's disease PARK7 was less than DJ-1 wt.[Function analysis of DJ-1 as protease] We analyzed the biochemical characterization of DJ-1 protease. Futhermore, we identified the recognition sequences for DJ-1 protease and targeted proteins.

[在氧化应激下分泌的DJ-1的功能分析]我们发现，来自星形胶质细胞的分泌DJ-1保护共培养神经元免受氧化应激。此外，我们发现家族性帕金森氏病PARK7中发现的分泌DJ-1突变体的量小于DJ-1 wt。[DJ-1作为蛋白酶的功能分析]我们分析了DJ-1蛋白酶的生化表征。 futhermore，我们确定了DJ-1蛋白酶和靶向蛋白的识别序列。

项目成果

Identification of the recognition sequence and target proteins for DJ-1 protease

• DOI: 10.1016/j.febslet.2013.06.032
• 发表时间: 2013-08-19
• 期刊: FEBS LETTERS
• 影响因子: 3.5
• 作者: Mitsugi, Hitomi;Niki, Takeshi;Ariga, Hiroyoshi
• 通讯作者: Ariga, Hiroyoshi

DJ-1のミトコンドリアにおける機能

DJ-1 在线粒体中的功能

• 发表时间: 2011
• 作者: 仁木(高橋)加寿子;仁木剛史;米田千夏;我那覇洋子;有賀(井口)早苗;有賀寛芳
• 通讯作者: 有賀寛芳

Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats.

• DOI: 10.1186/1750-1326-6-48
• 发表时间: 2011-07-08
• 期刊: Molecular neurodegeneration
• 影响因子: 15.1
• 作者: Kitamura Y;Watanabe S;Taguchi M;Takagi K;Kawata T;Takahashi-Niki K;Yasui H;Maita H;Iguchi-Ariga SM;Ariga H
• 通讯作者: Ariga H

Neuroprotective function of DJ-1 in Parkinson's disease.

• DOI: 10.1155/2013/683920
• 发表时间: 2013
• 期刊: Oxidative medicine and cellular longevity
• 作者: Ariga H;Takahashi-Niki K;Kato I;Maita H;Niki T;Iguchi-Ariga SM
• 通讯作者: Iguchi-Ariga SM

Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice.

• DOI: 10.1371/journal.pone.0078374
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Yamane T;Suzui S;Kitaura H;Takahashi-Niki K;Iguchi-Ariga SM;Ariga H
• 通讯作者: Ariga H