analysis of transposable genes in the tumors of hypersensitive individuals

过敏个体肿瘤中转座基因的分析

• 批准号: 23790439
• 负责人: KURABE Nobuya
• 金额: $ 2.75万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790439/
• 关键词: ゲノム不安定性; レトロトランスポゾン; LINE-1; インバース PCR; 次世代シーケンサー; インバースPCR

Genomic instability is one of the important regulatory mechanisms in the tumor development. The regulations of chromosome segregation and centrosome amplification are known to be involved in the genomic instability. Transposable genes “retrotransposons” are also implicated in it. In this study, although we used the more faster and high throughput technique compared with previous one, we could not find the tumor specific long interspersed element-1 (LINE-1, L1).

基因组稳定性是肿瘤发展中重要的调节机制。 -1（LINE-1，L1）。