Regulation of electronic cigarettes, which represent potential harm to public health.

对电子烟的监管，这对公共健康有潜在危害。

基本信息

批准号：
23650425
负责人：
KUNUGITA Naoki
金额：
$ 2.33万
依托单位：
National Institute of Public Health
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2011
资助国家：
日本
起止时间：
2011 至 2012
项目状态：
已结题

项目摘要

The electronic cigarette, introducedR recently to the marketplace, is a battery-powered device that provides tobacco-like smoke by heating a chemical solution into a vapor. There is, however, little information available regarding the safety of the electronic cigarette, because analysis of the smoke produced is very difficult due to the nature of the chemical components, e.g. acrolein and other carbonyls. Recently, we have developed an effective method for the determination of acrolein and other carbonyls using a dual-cartridge system, which consists of the first hydroquinone (HQ) cartridge for the inhibition of acrolein polymerization and the second 2,4-dinitrophenylhydrazine (DNPH) cartridge for the derivatization of carbonyls. All of the hydrazones derived from airborne carbonyls were completely separated and measured using HPLC. In this study, we analyzed carbonyl compounds generated by the electronic cigarette using the HQ-DNPH technique. Results showed that formaldehyde, acetaldehyde, acrolein, glyoxal and methyl glyoxal were contained in the electronic cigarette smoke. The maximum concentration of formaldehyde was 260 mg/m^3. Depending on the brand, cartridges usually contain humectants to produce the vapor (e.g. ethylene glycol, propylene glycol or glycerol) and flavors (e.g. tobacco, mint, fruit and chocolate). Therefore, a simple electronic cigarette was made, comprising a coiled Nichrom wire and glycols ; a voltage of 1.5～7.5 V was applied to the Nichrom wire. It was found that when the voltage exceeded 3 V, a mist containing carbonyl compounds was generated. From the results, it was elucidated that ethylene glycol was oxidized to formaldehyde and glyoxal ; propylene glycol was oxidized to formaldehyde, acetaldehyde and methylglyoxal ; and glycerol was oxidized to formaldehyde, acrolein, glyoxal and methylglyoxal.

该电子烟最近引入了市场，是一种电池供电的设备，通过将化学溶液加热到蒸气中，可提供类似烟草的烟雾。但是，几乎没有关于电子烟安全的信息，因为由于化学成分的性质，例如丙烯醛和其他羰基。最近，我们开发了一种有效的方法，可以使用双碳纤维系统确定丙烯醛和其他羰基，该系统由第一个氢喹酮（HQ）弹药组成，用于抑制丙烯醛聚合和第二个2，4-4-二硝基苯基羟基替嗪（DNPH）逆想者（DNPH）cartridge carbonyls odivativatization carbonyls。使用HPLC完全分离并测量了源自空气羰基的所有源自。在这项研究中，我们使用HQ-DNPH技术分析了电子民用部产生的羰基化合物。结果表明，甲醛，乙醛，丙烯醛，乙二醇和甲基乙二醇包含在电子烟中。甲醛的最大浓度为260 mg/m^3。根据品牌的不同，墨盒通常含有保湿剂以产生蒸气（例如乙二醇，丙烯甘油或甘油）和口味（例如烟草，薄荷，水果和巧克力）。因此，制成了简单的电子香烟，完成了一条盘绕的壁画线和甘油。将1.5-7.5 V的电压施加到Nichrom电线上。发现当电压超过3 V时，产生了含有MIS的含羰基化合物。从结果中可以阐明乙二醇被氧化为甲醛和乙二醛。将丙二醇氧化为甲醛，乙醛和甲醛。甘油被氧化为甲醛，丙烯醛，乙二醛和甲基乙二醛。