Tandem mass spectrometer coupled to a ultra-high performance liquid chromatograph

串联质谱仪与超高性能液相色谱仪联用

• 批准号: 540736575
• 金额: --
• 依托单位: Friedrich-Alexander-Universität Erlangen-Nürnberg
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2024
• 资助国家: 德国
• 起止时间: 2023-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/540736575?language=en
• 关键词: Tandem; mass; spectrometer; coupled; ultra

A system consisting of an ultra-high performance liquid chromatograph and a triple quadrupole mass spectrometer with linear ion trap and electrospray ionization is to be procured. The chromatographic system should consist of a binary high-pressure pump, a temperature-controlled column thermostat, an automatic sampler, and a temperature-controlled sampler. The tandem mass spectrometer shall have the highest sensitivity possible to make the analysis of very low concentrated compounds possible. Furthermore, the possibility of quantifying compounds by means of the so-called multiple reaction monitoring (MRM) mode should be given. For this reason, the acquisition of a hybrid triple quadrupole mass spectrometer with linear ion trap is intended. Another important component of the overall system is a powerful software that allows a reliable interpretation of the measurement data. The proposed system will be used mainly for the targeted analysis of small molecules, peptides and proteins. In addition, the system will be used to characterize bioactive food ingredients and their metabolites and to characterize reaction products from carbohydrates.

由超高性能液相色谱和带有线性离子陷阱和电喷雾电离的三重四极质谱仪组成的系统将被采购。色谱系统应由二元高压泵，温度控制的柱恒温器，自动采样器和温度控制的采样器组成。串联质谱仪应具有最高灵敏度，以使对非常低浓缩化合物的分析成为可能。此外，应给出通过所谓的多重反应监测（MRM）模式来量化化合物的可能性。因此，打算采购具有线性离子陷阱的杂化三倍四极大质谱仪。总体系统的另一个重要组成部分是一个强大的软件，可以对测量数据进行可靠的解释。所提出的系统将主要用于针对小分子，肽和蛋白质的靶向分析。此外，该系统将用于表征生物活性食品成分及其代谢产物，并表征来自碳水化合物的反应产物。