Function of immunocompetent cells in the tension zone of periodontal ligament in tooth movement

牙周膜张力区免疫活性细胞在牙齿移动中的作用

• 批准号: 23593052
• 负责人: NAKAMURA Yoshiki
• 金额: $ 3.24万
• 依托单位: Tsurumi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23593052/
• 关键词: 歯の移動; 牽引側歯根膜; 初期変化; 免疫系細胞; 単球、マクロファージ; MMP12; osterix; アルカリフォスファターゼ; エラスチン; コラーゲン線維; 歯根膜; 免疫関連因子; 遺伝子発現

Tissue reaction of the tension zone of periodontal ligament ( PDL ) during orthodontic tooth movement has been simplified as tugging of PDL fibers and bone formation. However, PDL fibers in the tension zone are forced to strong tugging, which causes involvement of defense system. We examined an involvement of immune system in the tension zone of PDL in early stage of tooth movement, using histological and immunohistochemical methods. Periodontal space was enlarged to more than 130 % and the PDL fibers showed a strong tugging aspect 6 hours after initiation of tooth movement. ED1 positive cells ( macrophage and monocyte ) were increased. However, fibroblasts also showed localization of IL-1B and MMP12. This indicats that fibroblasts involve in defense reaction of the PDL, prior to rearrangement of the PDL and bone formation on the alveolar bone in the very early stage of periodontal reaction in the tension zone.

正畸牙齿运动过程中牙周韧带（PDL）的张力区的组织反应已被简化为拉扯PDL纤维和骨形成。但是，张力区域中的PDL纤维被迫进行强大的拉力，这导致国防系统的参与。我们使用组织学和免疫组织化学方法检查了牙齿运动早期的PDL张力区域中免疫系统参与PDL的张力。牙周空间扩大到130％以上，PD​​L纤维在开始牙齿运动后6小时显示出强大的拉伸方面。 ED1阳性细胞（巨噬细胞和单核细胞）增加。但是，成纤维细胞也显示出IL-1B和MMP12的定位。这表明成纤维细胞参与PDL的防御反应，然后在张力区的牙周反应的早期阶段将PDL和骨形成在肺泡骨上。

项目成果

Effect of Chronic Akt/mTORInhibition by Rapamycinon Mechanical Overload-Induced Hypertrophy and Myosin Heavy Chain Transition in Masseter Muscle

雷帕霉素机械过载诱导的咬肌肥大和肌球蛋白重链转变对慢性 Akt/mTOR 抑制的影响

• 发表时间: 2013
• 期刊: J PharmacolSci
• 作者: UmekiD,OhnukiY,MototaniY;Nakamura Yetal
• 通讯作者: Nakamura Yetal

Regulations of osteoblastic survival at entheses.

附着点成骨细胞存活的调节。

• 发表时间: 2013
• 作者: Satoshi Wada;Akemi Shimada;Hisashi Ideno,Yoshiki Nakamura;Kazuhisa Nakashima;Akira Nifuji
• 通讯作者: Akira Nifuji

Fiber system degradation, and periostin and connective tissue growth factor level reduction, in the periodontal ligament of teeth in the absence of masticatory load

• DOI: 10.1111/j.1600-0765.2011.01351.x
• 发表时间: 2011-10-01
• 期刊: JOURNAL OF PERIODONTAL RESEARCH
• 影响因子: 3.5
• 作者: Choi, J. W.;Arai, C.;Nakamura, Y.
• 通讯作者: Nakamura, Y.

Expression of three histone3 lysine9 methyltransferases during mouse molar development

小鼠磨牙发育过程中三种组蛋白 3 赖氨酸 9 甲基转移酶的表达

• 发表时间: 2013
• 作者: 上運天太一;島田明美;出野尚;中村芳樹;木村宏;中島和久;二藤彰
• 通讯作者: 二藤彰

鶴見大学歯学部附属病院矯正科における顎変形症患者のDental Aesthetic Index

鹤见大学齿科医院正畸科颌骨畸形患者的牙齿美学指数

• 发表时间: 2014
• 期刊: 日本顎変形症学会雑誌
• 作者: 井出奈美;関谷利子;及川 崇;城所明光;中村芳樹
• 通讯作者: 中村芳樹