Pathogenic role of CADM-140 antigen (MDA5) in patients with dermatomyositis

CADM-140抗原（MDA5）在皮肌炎患者中的致病作用

• 批准号: 23591469
• 负责人: SATO Shinji
• 金额: $ 3.33万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591469/
• 关键词: 皮膚筋炎; 急速進行性間質性肺炎; 抗CADM-140抗体; 抗MDA5抗体; 間質性肺炎; 自己抗体; CADM; RP-ILD; MDA5; IFIH1; 皮膚筋炎; 急速進行性間質性肺炎; 抗CADM-140抗体; 抗MDA5抗体; 間質性肺炎; 自己抗体; CADM; RP-ILD; MDA5; IFIH1

Anti-CADM-140/MDA5 (Melanoma Differentiation-Associated Gene 5) antibody is a recently-reported antibody that recognized a 140 kDa polypeptide in patients with dermatomyositis (DM). This autoantibody has a close association with rapidly progressive interstitial lung disease (RP-ILD) and may be useful marker for presence of RP-ILD. In this study, we demonstrated close association between anti-CADM-140/MDA5 antibody titer by ELISA and RP-ILD disease activity in patients with DM and RP-ILD. Our findings also highlight the usefulness of this antibody not only in the prediction of RP-ILD but also in monitoring of the disease activity and prediction of disease outcome in daily clinical practice. Moreover, our data might be suggested that complexes of MDA5 and anti-CADM-140/MDA5 antibody might play a significant role in pathogenesis of RP-ILD and DM rather than being an epiphenomenon.

抗CADM-140/MDA5（黑色素瘤分化相关基因5）抗体是一种最​​近报告的抗体，在皮肤肌炎（DM）患者中识别140 kDa多肽。该自身抗体与快速进行性间质肺疾病（RP-ILD）有着密切的关联，对于存在RP-ILD可能是有用的标志物。在这项研究中，我们证明了DM和RP-ILD患者在ELISA和RP-ILD疾病活性的抗CADM-140/MDA5抗体滴度之间的密切关联。我们的发现还强调了该抗体在RP-ILD的预测中的有用性，而且还在监测日常临床实践中疾病活性和疾病预测的预测中的有用性。此外，我们的数据可能建议MDA5和抗CADM-140/MDA5抗体的复合物可能在RP-ILD和DM的发病机理中起重要作用，而不是Epipiphenomenon。