Immune response in the zinc-deficient mice infected with murine malaria.

感染鼠疟疾的缺锌小鼠的免疫反应。

• 批准号: 23590491
• 负责人: WATANABE HISAMI
• 金额: $ 3.24万
• 依托单位: University of the Ryukyus
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590491/
• 关键词: ネズミマラリア; 亜鉛欠乏; 自然免疫機構; Th2サイトカイン; 原虫特異抗体産性能; 獲得免疫機構

Malaria is one of the most serious infectious diseases worldwide. Therefore, there were many reports suggested the importance of nutritional status to maintain the immunity against pathogens. In particular, zinc is known to play a critical role in responding to infections including malaria. We have examined the relationship between zinc deficiency and murine malaria infection. The objective of this study is to explore the effect of zinc deficiency to the immunity against malaria.Mice fed with zinc deficient diet were infected with murine malaria parasites and the immunological parameters were sequentially analyzed. The results of this study indicated the zinc deficiency might affect the immune responses to malaria. The following is suggested; in early phase of infection, both innate immunity and phagocytic activities of macrophages can be maintained. However, acquired immune system might fail to induce the production of malaria specific antibodies to eliminate the parasites.

疟疾是全世界最严重的传染病之一。因此，有许多报道表明营养状况对于维持对病原体的免疫力的重要性。特别是，众所周知，锌在应对包括疟疾在内的感染方面发挥着关键作用。我们研究了锌缺乏与鼠疟疾感染之间的关系。本研究的目的是探讨缺锌对疟疾免疫的影响。以缺锌饲料喂养的小鼠感染鼠疟原虫，并对其免疫学参数进行连续分析。这项研究的结果表明，锌缺乏可能会影响对疟疾的免疫反应。建议如下；感染早期，先天免疫和巨噬细胞的吞噬活性均可维持。然而，获得性免疫系统可能无法诱导产生疟疾特异性抗体来消灭寄生虫。

项目成果

Sero-epidemiological survey of malaria in the border area of Quang Tri Province, Vietnam.

越南广治省边境地区疟疾血清流行病学调查

• 发表时间: 2013
• 作者: Watanabe;H.
• 通讯作者: H.

The importan t role of ssDNA-binding autoantibody secreting B cells in malaria infection

分泌B细胞的单链DNA结合自身抗体在疟疾感染中的重要作用

• 发表时间: 2011
• 作者: 李長春;Mannoor,K.,稲福征志;渡部久塞
• 通讯作者: 渡部久塞

nduction of ssDNA-binding autoantibody secreting B cell immunity during murine malaria infection is a critical part of the protective immune responses.

在小鼠疟疾感染期间诱导分泌 B 细胞免疫的 ssDNA 结合自身抗体是保护性免疫反应的关键部分。

• 发表时间: 2011
• 作者: Li;C.;Mannoor;K.;Watanabe;H.
• 通讯作者: H.

Immune response in the zinc-deficient mice infected with murine malaria

感染鼠疟疾的缺锌小鼠的免疫反应

• 发表时间: 2011
• 作者: Inamine;Y.;Li;C.;Inafuku;M.;Watanabe;H.
• 通讯作者: H.

Asymptomatic malaria, growth status and anemia among children in Savannakhet Province, Lao PDR

老挝人民民主共和国沙湾拿吉省儿童无症状疟疾、生长状况和贫血

• 发表时间: 2011
• 作者: Akiyama;T.;Taniguchi;T.;Inamine;Y.;Takeuchi;R.;Moji;K.;Kano;S.;Watanabe;H.
• 通讯作者: H.