Effects of MMP-9 on plaque rupture: development of a novel model for acute coronary syndromes.

MMP-9 对斑块破裂的影响：急性冠脉综合征新型模型的开发。

• 批准号: 23590401
• 负责人: WATANABE Teruo
• 金额: $ 3.33万
• 依托单位: Saga University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590401/
• 关键词: MMP-9; 動脈硬化; 遺伝子組換え; ウサギ; 病態モデル

Matrix metalloprotease (MMP)-9 transgenic (Tg) rabbits were analyzed to clarify the effects of MMP-9 on atherosclerosis. With high cholesterol diet loading, the arteriosclerotic lesion in MMP-9 Tg rabbit was larger than in control rabbit. Subsequently, MMP-9 Tg rabbit was mated with MMP-12 (known to accelerate the initiation of atherosclerosis) Tg rabbit and MMP-9/12 Tg rabbit was established as a candidate for a novel model for acute coronary syndromes.

分析了基质金属蛋白酶（MMP）-9转基因（TG）兔子，以阐明MMP-9对动脉粥样硬化的影响。随着胆固醇饮食的高负荷，MMP-9 TG兔中的动脉硬膜病变量大于对照兔中的动脉硬化病变。随后，将MMP-9 TG兔与MMP-12（已知可以加速动脉粥样硬化的开始）交配，TG兔子和MMP-9/12 TG兔被确立为急性冠状动脉综合征的新型模型的候选者。

项目成果

Overexpression of Peroxiredoxin 4 Attenuates Atherosclerosis in Apolipoprotein E Knockout Mice

• DOI: 10.1089/ars.2012.4549
• 发表时间: 2012-11-01
• 期刊: ANTIOXIDANTS & REDOX SIGNALING
• 影响因子: 6.6
• 作者: Guo, Xin;Yamada, Sohsuke;Sasaguri, Yasuyuki
• 通讯作者: Sasaguri, Yasuyuki

Peroxiredoxin 4 Protects Against Nonalcoholic Steatohepatitis and Type 2 Diabetes in a Nongenetic Mouse Model

• DOI: 10.1089/ars.2012.4946
• 发表时间: 2013-12-10
• 期刊: ANTIOXIDANTS & REDOX SIGNALING
• 影响因子: 6.6
• 作者: Nabeshima, Atsunori;Yamada, Sohsuke;Sasaguri, Yasuyuki
• 通讯作者: Sasaguri, Yasuyuki