Multilateral verification of preventive effects of polyunsaturated fatty acids on dementia

多不饱和脂肪酸对痴呆症预防作用的多边验证

• 批准号: 23500955
• 负责人: HASHIMOTO Michio
• 金额: $ 3.33万
• 依托单位: Shimane University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500955/
• 关键词: 多価不飽和脂肪酸; 認知症予防; リピドミクス; 多価不飽和脂肪酸メディエーター; ヒト介入試験; Madecassoside; 天然物由来アルツハイ; 遺伝子多型; 生活習慣病発症マーカー遺伝子多型; Δ5不飽和化酵素遺伝子多型; 天然物由来アルツハイマー病予防物質; n-3系多価不飽和脂肪酸; 神経新生; 縦断型疫学研究; うつ; リピドミックス; ドコサノイド; 認知症予防物質の探索; 一分子蛍光分析; LC/MS/MS; ナノ微粒子質量分析; βアミロイド

From the sub-analysis of human interventional studies on dementia prevention, both the groups were subdivided according to the mean changes in the total MMSE (dMMSE) scores over 12 months as following: responders, total dMMSE change > 0; nonresponders, total dMMSE score change < 0. The levels of plasma LDL-cholesterol and erythrocyte eicosapentaenoic acid were significant higher in the responders than those in the nonresponders, suggesting that the nutrition status of the elderly is reflected in dementia preventive effect by DHA-enriched food. The differences of genetic polymorphisms of delta 5 desaturase were, however, not observed between two groups.Using a TSQ quantum mass spectrometer, the positive correlation between the improvement of spatial cognitive learning ability in DHA-administrated aged rats and the brain levels of DHA-derived metabolites was found. Visualization of decreased DHA in the hippocampus of rats by imaging mass spectrometry was established.

从痴呆预防人类干预研究的亚分析中，根据 12 个月内总 MMSE（dMMSE）评分的平均变化对两组进行细分：应答者，总 dMMSE 变化 > 0；无应答者，总 dMMSE 评分变化 < 0。应答者血浆 LDL-胆固醇和红细胞二十碳五烯酸水平显着高于无应答者，表明老年人的营养状况反映了富含 DHA 的痴呆预防效果食物。然而，两组之间未观察到δ 5去饱和酶基因多态性的差异。使用TSQ量子质谱仪发现，给予DHA的老年大鼠空间认知学习能力的改善与脑中DHA水平呈正相关。发现了衍生代谢物。通过成像质谱法建立了大鼠海马 DHA 减少的可视化。

项目成果

Effects of Krill-derived phospholipid-enriched n-3 fatty acids on Ca(2+) regulation system in cerebral arteries from ovariectomized rats

磷虾磷脂n-3脂肪酸对去势大鼠脑动脉Ca(2)调节系统的影响

• DOI: 10.1016/j.lfs.2014.01.070
• 发表时间: 2014
• 期刊: Life Sciences
• 影响因子: 6.1
• 作者: Yasushi Sakai;Michio Hashimoto;Budbazar Enkhjargal;Hisashi Mitsuishi;Hiromi Nobe;Ichiro Horie;Takahiro Iwamoto;Kenichi Yanagimoto
• 通讯作者: Kenichi Yanagimoto

Association of marine-origin N-3 polyunsaturated fatty acids consumption and functional mobility in the community-dwelling oldest old

• DOI: 10.1007/s12603-012-0389-1
• 发表时间: 2012
• 期刊: The journal of nutrition, health & aging
• 作者: M. Takayama;Y. Arai;Satoshi Sasaki;Michio Hashimoto;K. Shimizu;Yukiko Abe;N. Hirose

多価不飽和脂肪酸摂取によるラット骨格筋の筋線維型に及ぼす影響

多不饱和脂肪酸摄入对大鼠骨骼肌肌纤维类型的影响

• 发表时间: 2013
• 作者: 井上隆之;橋本道男;片倉賢紀;田邉洋子;Abdullah Al Mamun;大谷 浩;紫藤 治
• 通讯作者: 紫藤 治

Mechanism of neurotoxicity of amyloid-beta peptide and the protective effects.

β淀粉样肽的神经毒性机制及其保护作用。

• 发表时间: 2012
• 作者: Michio Hashimoto;Hossain Md Shahdat;Masanori Katakura;飯塚由美;Shahdat Hossain and Michio Hashimoto
• 通讯作者: Shahdat Hossain and Michio Hashimoto

Neuroprotective effect of madecassoside: Evaluated in amyloid β 1-42 -infused Alzheimer's disease model rats. International Chemical Biology Society

羟基积雪草苷的神经保护作用：在注入淀粉样蛋白 β 1-42 的阿尔茨海默病模型大鼠中进行评估。

• 发表时间: 2013
• 作者: A Al Mamun;M Hashimoto;M Katakura;他 3名 ( 2 番 目 )
• 通讯作者: 他 3名 ( 2 番 目 )