The role of lipid metabolism in prostate cancer

脂质代谢在前列腺癌中的作用

• 批准号: 23390378
• 负责人: SUZUKI Kazuhiro
• 金额: $ 6.82万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390378/
• 关键词: 前立腺癌; 脂質; 脂質代謝; 副腎性アンドロゲン; スタチン

Various basic studies were conducted to elucidate the effect of lipids on prostate cancer. First, squalene synthase, which is the key enzyme in mevalonate pathway is evaluated. Our previous study revealed that the SNP of FDFT1, which encodes squalene synthase, was associated with risk of prostate cancer development. The present study showed that down-regulation of FDFT1 gene expression led to significant inhibition of cancer proliferation. Furthermore, the FDFT1 gene expression levels were correlated with biological aggressiveness of prostate cancer. Next, the effect of statin was evaluated as to LDL receptor. Prostate cancer cells were the target of statin. Statin regulated both LDL receptor expression profiles and cholesterol content in the cell. These regulatory events were relevant to prostate cancer proliferation. Finally, the effect of metformin was evaluated. Metformin inhibit prostate cancer proliferation via down-regulation of IGF1-receptor.

进行了各种基础研究来阐明脂质对前列腺癌的影响。首先，评估甲羟戊酸途径中的关键酶角鲨烯合酶。我们之前的研究表明，编码角鲨烯合酶的 FDFT1 的 SNP 与前列腺癌发生的风险相关。本研究表明，FDFT1 基因表达下调可显着抑制癌症增殖。此外，FDFT1基因表达水平与前列腺癌的生物侵袭性相关。接下来，评价他汀类药物对LDL受体的作用。前列腺癌细胞是他汀类药物的靶标。他汀类药物可调节细胞中的 LDL 受体表达谱和胆固醇含量。这些调节事件与前列腺癌增殖相关。最后评估二甲双胍的效果。二甲双胍通过下调 IGF1 受体抑制前列腺癌增殖。

项目成果

LDL receptor plays an important role in inhibition of prostate cancer cell proliferation by statin

LDL受体在他汀类药物抑制前列腺癌细胞增殖中发挥重要作用

• 发表时间: 2012
• 作者: Furuya Y;et al
• 通讯作者: et al

Diagnostic significance of [-2]pro-PSA and prostate dimension-adjusted PSA-related indices in men with total PSA in the 2.0-10.0 ng/mL range

• DOI: 10.1007/s00345-012-0927-9
• 发表时间: 2013-04-01
• 期刊: WORLD JOURNAL OF UROLOGY
• 影响因子: 3.4
• 作者: Ito, Kazuto;Miyakubo, Mai;Suzuki, Kazuhiro
• 通讯作者: Suzuki, Kazuhiro

Metformin inhibits the proliferation of human prostate cancer PC-3 cells via down-regulation of the insulin-like growth factor 1 receptor

二甲双胍通过下调胰岛素样生长因子1受体抑制人前列腺癌PC-3细胞的增殖

• 发表时间: 2014
• 作者: Kato H;Sekine Y;Miyazawa Y;Furuya Y;Koike H;Suzuki K
• 通讯作者: Suzuki K

Effects of LH-RH agonist on hormonal and cognitive function of prostate cancer patients in relation to testicular and adrenal androgens

LH-RH 激动剂对前列腺癌患者与睾丸和肾上腺雄激素相关的激素和认知功能的影响

• 发表时间: 2012
• 作者: Makiyama K;Sakata R;Yamanaka H;Tatenuma T;Sano F;Kubota Y;Suzuki K
• 通讯作者: Suzuki K

去勢抵抗性前立腺癌発症の基礎的検討：脂質代謝に関して

去势抵抗性前列腺癌发展的基础研究：关于脂质代谢

• 作者: 関根芳岳;鈴木和浩
• 通讯作者: 鈴木和浩