Genetic analysis of prostate cancer susceptibility performing genomewide homozygosity haplotype analysis

前列腺癌易感性的遗传分析进行全基因组纯合单倍型分析

• 批准号: 20390419
• 负责人: SUZUKI Kazuhiro
• 金额: $ 9.32万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390419/
• 关键词: 前立腺癌; 遺伝子解析; スクアレン合成酵素; FDFT1; 家族性前立腺癌; HDL; LDL

We analyzed the genomic DNA using genomewide homozyosity haplotype analysis to identify the susceptibility gene for familial/hereditary prostate cancer. Through previous studies and the present study, we found the significant association of prostate cancer risk with the gene encoding squalene synthase, i.e., farnesyldiphosphate farnesyltrasfrerase (FDFT1). The AA+AG genotypes of SNP in the promoter region, rs2645429 was found significantly in patients with cases. Functional analysis of FDFT1 showed the elevation of promoter activity in the A type promoter, and that the squalene synthase has close relations to prostate cancer growth.

我们使用全基因组纯合单倍型分析来分析基因组 DNA，以确定家族性/遗传性前列腺癌的易感基因。通过之前的研究和本研究，我们发现前列腺癌风险与编码角鲨烯合酶的基因（即法尼基二磷酸法尼基转移酶（FDFT1））显着相关。病例患者启动子区rs2645429的SNP AA+AG基因型显着存在。 FDFT1的功能分析表明A型启动子中的启动子活性升高，角鲨烯合酶与前列腺癌的生长密切相关。

项目成果

High fat diet reduces the expression of glutathione peroxidase 3 in mouse prostate.

• DOI: 10.1002/pros.21365
• 发表时间: 2011-10-01
• 期刊: PROSTATE
• 影响因子: 2.8
• 作者: Sekine, Yoshitaka;Osei-Hwedieh, David;Matsuda, Kant;Raghavachari, Nalini;Liu, Delong;Furuya, Yosuke;Koike, Hidekazu;Suzuki, Kazuhiro;Remaley, Alan T.
• 通讯作者: Remaley, Alan T.

Association between common sequence variants in the FDFT1 gene and the prostate cancer risk in the Japanese population.

FDFT1 基因中常见序列变异与日本人群前列腺癌风险之间的关联。

• 发表时间: 2009
• 作者: Fukuma Y;Matsui H;Hamano T;Ohtake N;Nakata S;Suzuki K
• 通讯作者: Suzuki K

High-density lipoprotein induces proliferation and migration of human prostate androgen-independent cancer cells by an ABCA1-dependent machanism.

高密度脂蛋白通过 ABCA1 依赖性机制诱导人前列腺雄激素非依赖性癌细胞的增殖和迁移。

• 发表时间: 2010
• 期刊: Mel Cancer Res 8(9)
• 作者: Sekine Y;Demosky SJ;Stonik JA;Furuya Y;Koike H;Suzuki K;Remaley AT
• 通讯作者: Remaley AT

High density lipoprotein induces proliferation and migration of human nrostate cancer cells by an ARCAI-denedent mechanism

高密度脂蛋白通过 ARCAI 机制诱导人前列腺癌细胞的增殖和迁移

• 发表时间: 2010
• 期刊: Mol Cancer Res
• 影响因子: 5.2
• 作者: Sekine Y;et al(全7名)
• 通讯作者: et al(全7名)

Survivin is associated with cell proliferation and plays a role in 1a,25-dihydrovitamin D3 induced cell growth inhibition in prostate cancer.

生存素与细胞增殖相关，并在 1a,25-二氢维生素 D3 诱导的前列腺癌细胞生长抑制中发挥作用。

• 发表时间: 2009
• 作者: Koike H;Sekine Y;Morikawa Y;Arai S;Furuya Y;Matsui H;Shibata Y;Suzuki K
• 通讯作者: Suzuki K