Urine metabolomics analysis for autistic spectrum disorder

自闭症谱系障碍的尿液代谢组学分析

• 批准号: 22659211
• 负责人: MINABE Yoshio
• 金额: $ 1.98万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659211/
• 关键词: 児童・思春期精神医学; メタボローム解析; 尿メタボローム; 脂肪酸; 広汎性発達障害; 就学前児童; 脳磁図計; ガスクロマトグラフ質量分析法; ガスクロマトグラフ量分析法; 児童・思春期精神医学; メタボローム解析; 尿メタボローム; 脂肪酸; 広汎性発達障害; 就学前児童; 脳磁図計; ガスクロマトグラフ質量分析法; ガスクロマトグラフ量分析法

Because of its characteristics and simple non-invasive methods of collection, urine is particularly suited for metabolomic analysis even in young children. We explore urine fatty acid metabolic substance as a biomarker for autism spectrum disorder. In 32 ASD children and 24 typically developing(TD) young children(3-7 years old), 7 fatty acid metabolic substances(i. e., myristic acid, palmitic acid, linoleic acid, oleic acid, stearic acid, arachidic acid, behenic acid) in urine were quantified using gas chromatography. mass spectrometry. As a result, there were no significant differences in these concentrations between ASD and TD children. In addition, there were no significant correlations between cognitive performances and these concentrations.

由于其特征和简单的非侵入性收集方法，尿液即使在幼儿中也特别适合代谢组分析。我们探索尿液脂肪酸代谢物质作为自闭症谱系障碍的生物标志物。在32名ASD儿童和24个通常发育的（TD）幼儿（3-7岁）中，7种脂肪酸代谢物质（即，肉豆蔻酸，棕榈酸，亚油酸，油酸，油酸，脂肪酸，果酸，蛛网酸，蜂巢酸，贝内酸）在尿液中被使用气体量进行定量。质谱法。结果，ASD和TD儿童之间的这些浓度没有显着差异。另外，认知性能与这些浓度之间没有显着的相关性。