Serotonin transporter loss and psychotic state in methamphetamine users

甲基苯丙胺使用者的血清素转运蛋白丢失和精神病状态

• 批准号: 15390349
• 负责人: MINABE Yoshio
• 金额: $ 4.86万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15390349/
• 关键词: methamphetamine; serotonin transpoter; aggression; PET; proton MRS; toluene; human; methamphetamine; serotonin transpoter; aggression; PET; proton MRS; toluene; human

Background : In animals, methamphetamine is known to have a neurotaxic effect on seroronin neurons, which have been implicated in the regulation of mood, anxiety, and aggression. However, it remains unknown whether or not methamphetamine damages serotonin neurons in humans.Objective : To investigate the status of brain serotonin neurons and their possible relationship with clinical characteristics in currently abstinent former methamphetamine abusers.Desigh : The brain regional density of the serotonin transporter, a structural component of serotonin neurons, was estimated in the brain using positron emission tomography (PET) and [^<11>C](+)McN-5652. A case-control analysis was performed with the estimates derived from region-of-interest (ROI) and statistical parametric mapping (SPM) methods, followed by within-case analysis with the measures of clinical variables.Setting : Partieipants were recruited from the community to a hospital research center.Participants : Twelve currently abst … More inent former methamphetamine abusers (5 women, 7 men) and age-, gender-, and twelve education-matched healthy control subjects (5 women, 7 men).Main Outcome Measures : The duration of methamphetamine use, magnitude of aggression and depressive symptoms, and changes in serotonin transporter density represented by the [^<11>C](+)McN-5652 distribution volume.Results : The methamphetamine abusers showed increased levels of aggression compared to those of the control subjects. Both ROI and SPM analyses revealed that the serotonin transporter density in global brain regions (eg, midbrain, thalamus, caudate, putamen, cerebral cortex, and cerebellum) was significantly lower in the methamphetamine abusers than in the control subjects, and this reduction was found to be significantly inversely correlated with the duration of methamphetamine use. Furthermore, SPM analyses indicated that the density in the orbitofrontal, temporal, and anterior cingulate areas was closely associated with the magnitude of aggression in methamphetamine abusers.Conclusions : Protracted abuse of methamphetamine may reduce the density of the serotonin transporter in the brain, leading to elevated aggression, even among those in a currently abstinent state. Less

背景：在动物中，已知甲基苯丙胺对塞拉隆蛋白神经元具有神经毒性作用，这在情绪，焦虑和侵略性的调节中被暗示。 However, it remains unknown whether or not methamphetamine damages seratonin neurons in humans.Objective: To investigate the status of brain seratonin neurons and their possible relationship with clinical characteristics in currently abstinent former methamphetamine abusers.Desigh: The brain regional density of the serotonin transporter, a structural component of serotonin neurons, was estimated in the brain using polar emission tomography （PET）和[^<11> C]（+）MCN-5652。 A case-control analysis was performed with the estimates derived from region-of-interest (ROI) and statistical parametric mapping (SPM) methods, followed by within-case analysis with the measures of clinical variables.Setting: Partieipants were recruited from the community to a hospital research center.Participants: Twelve currently abst … More inent former methamphetamine abusers (5 women, 7 men) and age-,性别 - 和十二个教育匹配的健康对照受试者（5名女性，7名男性）。良好的结果指标：甲基苯丙胺使用的持续时间，侵略性和抑郁症状的幅度以及由[^<11> c]（+）MCN-5652分布的甲基分布量增加的血清素转运蛋白转运蛋白的变化：主题。 ROI和SPM分析均表明，全球脑区域中的5-羟色胺转运蛋白转运蛋白（例如中脑，丘脑，丘脑，尾状，梭子，梭子，脑皮质和小脑）在甲基苯丙胺滥用者中明显低于对照组的甲基苯丙胺滥用者，并且与对照组相比，与对照组相比，与耐药的相关性均高于这种限制。此外，SPM分析表明，甲型甲基苯丙胺滥用器的侵略性的幅度与甲基苯丙胺的滥用量可能会降低脑体素的密度，从而导致甲基苯胺的密度降低，并且在这些脑中的大脑中，当前均高于A的攻击中，甲基苯丙胺的密度与甲基苯丙胺的密度密切相关。