patho-physiologic role of HSP90 in the aseptic inflammatory process

HSP90 在无菌炎症过程中的病理生理作用

• 批准号: 22659075
• 负责人: SATO Noriyuki
• 金额: $ 1.98万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659075/
• 关键词: 分子病理; HSP; 抗原提示細胞; 自然免疫; CTL; 癌ワクチン; endosome; IFNα

This study was intended to analyze patho-physiologic role of heat shock protein 90(HSP90) in the aseptic inflammatory process. Specifically we tried to identify HSP90 receptor molecule that is considered to be expressed on inflammatory cells such as macrophages and dendritic cells. We successfully obtained such candidate molecules, and it may be possible to regulate the pathologic inflammatory process involving with these molecule.

本研究旨在分析热休克蛋白90（HSP90）在无菌炎症过程中的病理生理作用。具体来说，我们试图鉴定被认为在巨噬细胞和树突状细胞等炎症细胞上表达的 HSP90 受体分子。我们成功获得了这样的候选分子，这些分子有可能调控炎症的病理过程。

项目成果

Tumor associated dendritic cells : molecular mechanisms to suppress anti-tumor immunity

肿瘤相关树突状细胞：抑制抗肿瘤免疫的分子机制

• DOI: 10.2217/imt.11.94
• 发表时间: 2011
• 期刊: Immunotherapy
• 影响因子: 2.8
• 作者: Hirohashi;Y. and Sato;N.
• 通讯作者: N.

Immune response against tumor antigens expressed on human cancer stem-like cells/tumor-initiating cells

• DOI: 10.2217/imt.10.10
• 发表时间: 2010-03-01
• 期刊: IMMUNOTHERAPY
• 影响因子: 2.8
• 作者: Hirohashi, Yoshihiko;Torigoe, Toshihiko;Sato, Noriyuki
• 通讯作者: Sato, Noriyuki

The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma

• DOI: 10.1016/j.yexmp.2010.10.001
• 发表时间: 2011-02-01
• 期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY
• 影响因子: 3.6
• 作者: Inoda, Satoko;Morita, Rena;Sato, Noriyuki
• 通讯作者: Sato, Noriyuki

Spatiotemporal Regulation of Heat Shock Protein 90-Chaperoned Self-DNA and CpG-Oligodeoxynucleotide for Type I IFN Induction via Targeting to Static Early Endosome

• DOI: 10.4049/jimmunol.1000490
• 发表时间: 2010-06-15
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Okuya, Koichi;Tamura, Yasuaki;Sato, Noriyuki
• 通讯作者: Sato, Noriyuki

Efficiency of G2/M-related tumor-associated antigen-targeting cancer immunotherapy depends on antigen expression in the cancer stem-like population

• DOI: 10.1016/j.yexmp.2011.09.016
• 发表时间: 2012-02-01
• 期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY
• 影响因子: 3.6
• 作者: Mori, Takashi;Nishizawa, Satoshi;Sato, Noriyuki
• 通讯作者: Sato, Noriyuki