Molecular immunopathology of human cancer stem cell

人类癌症干细胞的分子免疫病理学

• 批准号: 21249025
• 负责人: SATO Noriyuki
• 金额: $ 29.45万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21249025/
• 关键词: 分子病理; 癌幹細胞; 腫瘍抗原; CTL; 癌免疫; 分子標的; SP法; CSC/CIC; CSC; CIC

This study was aimed to analyze molecular pathological nature of human cancer stem cell(CSC)/cancer-initiating cell(CIC). Particularly we studied molecules expressed specifically in CSC/CIC and their immunological characteristics. Consequently we successfully identified such interesting antigens. These antigens have molecular features of cancer-testis antigens, and could work as potential immunogenic molecule in human cancers.

本研究旨在分析人类癌症干细胞（CSC）/癌症起始细胞（CIC）的分子病理性质。我们特别研究了 CSC/CIC 中特异表达的分子及其免疫学特征。因此，我们成功地鉴定了这些有趣的抗原。这些抗原具有癌症睾丸抗原的分子特征，可以作为人类癌症中潜在的免疫原性分子。

项目成果

Tumor associated dendritic cells : molecular mechanisms to suppress anti-tumor immunity

肿瘤相关树突状细胞：抑制抗肿瘤免疫的分子机制

• DOI: 10.2217/imt.11.94
• 发表时间: 2011
• 期刊: Immunotherapy
• 影响因子: 2.8
• 作者: Hirohashi;Y. and Sato;N.
• 通讯作者: N.

Stress Response Genes Expressed in Cancer Stem Cells-potent molecular targets for cancer therapy

癌症干细胞中表达的应激反应基因——癌症治疗的有效分子靶标

• 发表时间: 2011
• 作者: Toshihiko Torigoe;Hirohashi Yoshihiko;Yasuaki Tamura;Noriyuki Sato
• 通讯作者: Noriyuki Sato

A novel DNAJ family protein is a cancer initiating cell antigen.-A potent molecular target for cancer immunotherapy

一种新型 DNAJ 家族蛋白是癌症起始细胞抗原。-癌症免疫治疗的有效分子靶点

• 发表时间: 2010
• 作者: Toshihiko Torigoe;Yoshihiko Hirohashi;Satoshi Nishizawa;Akari Takahashi;Hiroko Asanuma;Munehide Nakatsugawa;Kenjiro Kamiguchi;Alisa A. Sokolovskaya;Noriyuki Sato
• 通讯作者: Noriyuki Sato

がん幹細胞分子マーカー

肿瘤干细胞分子标志物

• 发表时间: 2008

Tumor-Produced Secreted Form of Binding of Immunoglobulin Protein Elicits Antigen-Specific Tumor Immunity. Selected paper in "In thia issue" of the Journal

肿瘤产生的免疫球蛋白结合的分泌形式引发抗原特异性肿瘤免疫。

• 发表时间: 2011
• 期刊: J.Immunol.
• 作者: Tamura Y.;Sato;N.;et al.
• 通讯作者: et al.