Evaluation of a hypothesis that "The intestinal detoxification system can be regulated by eating"

“肠道排毒系统可以通过饮食调节”假说的评价

• 批准号: 22658040
• 负责人: SHIMIZU Makoto
• 金额: $ 2.34万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22658040/
• 关键词: 食品; 解毒代謝; 腸管バリア; 解毒酵素系; Caco-2細胞; アリルハイドロカーボン受容体; ダイオキシン; フラボノイド; 遺伝子発現変化; 腸管

Dioxin-induced expression of intestinal detoxification enzymes(DTE), such as CYPs, was suppressed by flavonoids. The CYP expression was also induced by certain flavonoids. DNA microarray analysis showed that dioxins and flavonoids caused different gene expression of intestinal DTE. Among eight flavonoids having the AhR agonistic activity, only one of them was able to induce regulatory T cell differentiation via AhR activation, suggesting that a small difference in the AhR/ligand interaction was responsible for the variability of gene expression.

二恶英诱导的肠道解毒酶（DTE）（例如CYPS）的表达被类黄酮抑制。某些类黄酮也诱导了CYP表达。 DNA微阵列分析表明，二恶英和类黄酮引起肠道DTE的不同基因表达。在具有AHR激动活性的八种类黄酮中，只有一个能够通过AHR激活诱导调节性T细胞分化，这表明AHR/配体相互作用的差异很小，导致基因表达的变异性。

项目成果

Dietary flavonoid naringenin induces regulatory T cells via an aryl hydrocarbon receptor(AhR)-mediated pathway

膳食类黄酮柚皮素通过芳烃受体 (AhR) 介导的途径诱导调节性 T 细胞

• 发表时间: 2012
• 期刊: J. Agric. Food Chem.
• 影响因子: 6.1
• 作者: Wang;H-K.;Yeh;C-H.;Iwamoto;T.;Satsu;H.;Shimizu;M.;Totsuka;M.
• 通讯作者: M.

Screening and evaluation of dietary arylhydrocarbon receptors(AhR) ligands inducing differentiation of regulatory T cells

膳食芳烃受体（AhR）配体诱导调节性T细胞分化的筛选和评价

• 发表时间: 2011
• 作者: Wang;H-K.;Iwamoto;T.;Satsu;H.;Shimizu;M.;Totsuka;M
• 通讯作者: M

Modulation of intestinal barrier functions by food

食物对肠道屏障功能的调节

• 发表时间: 2011
• 作者: Shimizu;M.
• 通讯作者: M.

Naringeninと食品由来AHRリガンドによるマウス制御性T細胞の誘導機能

柚皮素和食物来源的 AHR 配体对小鼠调节性 T 细胞的诱导功能

• 发表时间: 2011
• 作者: 王璽凱;他
• 通讯作者: 他

Induction of detoxification enzymes by equol via activation of pregnane X receptor in human intestinal epithelial cells

雌马酚通过激活人肠上皮细胞中孕烷X受体诱导解毒酶

• 发表时间: 2011
• 作者: Satsu;H.
• 通讯作者: H.