Development of a novel charged-particle therapy combined with effects of tumor blood flow interruption

结合肿瘤血流中断效应的新型带电粒子疗法的开发

• 批准号: 22650113
• 负责人: TERAKAWA Atsuki
• 金额: $ 2.17万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22650113/
• 关键词: 粒子線治療; 腫瘍血流遮断剤; 超高分解能PET; 陽子線治療; 腫瘍血流遮断薬; PET

Therapeutic experiments were performed based on a murine solid tumor to develop a novel combined-treatment between proton therapy and a vascular disrupting agent AVE8062. Therapeutic effects on tumor growth were evaluated from high spatial resolution PET using [18F] Fluoro-Deoxy-Glucose and [18F] Fluoromisonidazole. The results of the PET scans show that a single combined treatment between proton therapy and AVE8062 caused extensive necrosis in the inner region of the tumor, while tumor cells in the tumor periphery survived the single treatment. It is suggested that the tumor receiving the single combined-treatment can be cured after the second proton irradiation.

基于小鼠实体瘤进行治疗实验，开发质子疗法和血管破坏剂 AVE8062 之间的新型联合治疗方法。使用[18F]氟脱氧葡萄糖和[18F]氟罗米索硝唑通过高空间分辨率PET评估对肿瘤生长的治疗效果。 PET扫描结果显示，质子疗法和AVE8062的单一联合治疗导致肿瘤内部区域广泛坏死，而肿瘤外围的肿瘤细胞在单一治疗中存活下来。建议单次联合治疗的肿瘤在第二次质子照射后即可治愈。

项目成果

PIXE ANALYSIS OF A MURINE FIBROSARCOMA TUMOR FOR PROTON THERAPY COMBINED WITH THE CHEMOTHERAPEUTIC AGENT CISPLATIN

质子治疗联合化疗药物顺铂对小鼠纤维肉瘤肿瘤的 PIXE 分析

• 发表时间: 2010
• 期刊: International Journal of PIXE Vol.20 3&4
• 作者: A.TERAKAWA;Y.ITO;K.ISHII;S.MATSUYAMA;Y.KIKUCHI;S.YASUNAGA;A.TAGAWA;T.KAWAMURA;Y.TAKAHASHI;Y.HATORI;N.HAMADA;K.FUJIKI;H.YAMAZAKI;Y.FUNAKI;N.ITO;S.WADA;K.SERA
• 通讯作者: K.SERA

PIXE analysis of murine solid tumor treated with proton therapy combined with cisplatin

质子治疗联合顺铂治疗小鼠实体瘤的PIXE分析

• 发表时间: 2010
• 作者: A. Terakawa;A.Terakawa
• 通讯作者: A.Terakawa

Submilli-PIXE analysis of a murine fibrosarcoma tumor treated with proton therapy combined with cisplatin

质子治疗联合顺铂治疗的小鼠纤维肉瘤肿瘤的 Submilli-PIXE 分析

• 发表时间: 2011
• 作者: T.Kawamura;Y.Ito;A.Terakawa;K.Ishii;et al
• 通讯作者: et al

PIXE ANALYSIS OF A MURINE FIBROSARCOMA TUMOR TREATED WITH A VASCULAR DISRUPTING AGENT AVE8062

用血管干扰剂 AVE8062 治疗的鼠纤维肉瘤肿瘤的 PIXE 分析

• 发表时间: 2011
• 期刊: International Journal of PIXE
• 作者: A. TERAKAWA;K. ISHII;S. MATSUYAMA et a
• 通讯作者: S. MATSUYAMA et a