Study of the new minimally-invasive proton therapy with antivascular effects

具有抗血管作用的新型微创质子治疗研究

基本信息

批准号：
17300169
负责人：
TERAKAWA Atsuki
金额：
$ 9.46万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

项目摘要

Antitumor effects of the proton therapy in combination with the combretastatin A-4 derivative, AVE8062 were studied by using NFSa fibrosarooma implanted into the hind legs of C3H/He mice in order to investigate the minimally invasive treatment technique in proton therapy with antivassular effects.The proton therapy facilities for small animals were developed to perform the treatment experiments on the tumor mouse model at Cyclotron and Radioisotope Center (CYRIC), Tohoku University. In addition, proton-irradiation experiments with a dog tumor cell of squamous cell carcinoma were performed to derive the relative biological effectiveness (RBE) of a therapeutic 80-MeV proton beam compared to a gamma ray of ^<6O>Co. The RBE of the 80 MeV proton was 1.4-1.6 at the Bragg peak, 1.1 at the spread-out Bragg peak.The time course of a tumor growth was measured after a single irradiation of the proton beam and/or a single intraperitoneal administration of AVE8062. The proton irradiation provided large antitumor effects such as a tumor volume reduction and a tumor growth delay (TGD) depending on the proton absorbed dose ( 15 or 30 Gy ), while there were not significant differences in TGD between the AVE8062 administration groups ( 5 or 10 mg/kg) and an unirradiated control. The proton irradiation in combination with the AVE8062 administration resulted in the almost same TGD as the monotherapy of proton irradiation. The present results suggest that it is important to optimize the protocol for the combined treatment to provide a larger antitumor effect compared to the monotherapy.

通过将NFSa纤维肉瘤植入C3H/He小鼠后腿，研究质子治疗联合考布他汀A-4衍生物AVE8062的抗肿瘤作用，探讨质子治疗抗血管作用的微创治疗技术。东北大学回旋加速器和放射性同位素中心（CYRIC）开发了小动物质子治疗设备，用于对肿瘤小鼠模型进行治疗实验。另外，用鳞状细胞癌的狗肿瘤细胞进行质子辐照实验，以得出治疗性80-MeV质子束与6O Co的伽马射线相比的相对生物有效性(RBE)。 80MeV质子的RBE在布拉格峰处为1.4-1.6，在扩散布拉格峰处为1.1。在单次质子束照射和/或单次腹膜内施用质子束后测量肿瘤生长的时间进程。 AVE8062。质子照射提供了很大的抗肿瘤作用，例如肿瘤体积减小和肿瘤生长延迟（TGD），具体取决于质子吸收剂量（15或30 Gy），而AVE8062给药组（5或30 Gy）之间的TGD没有显着差异。 10 mg/kg）和未辐照对照。质子照射与 AVE8062 联合给药产生的 TGD 与质子照射单一疗法几乎相同。目前的结果表明，优化联合治疗方案以提供比单一疗法更大的抗肿瘤效果非常重要。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Basic study on the spot-beam scanning irradiation technique for the CYRIC proton-therapy facilities for small animals

CYRIC小动物质子治疗装置点束扫描照射技术的基础研究

DOI：
发表时间：
2007
期刊：
影响因子：
0
作者：
A. Terakawa ;et. al.;A. Terakawa et. al.;A.Terakawa;寺川貴樹;寺川貴樹;A. Terakawa ed. al.;寺川貴樹;寺川貴樹;宮下拓也;A. Terakawa ed. al.;T. Miyashita ed. al.
通讯作者：
T. Miyashita ed. al.

Status Report of Sasaki Taro Memorial PIXE Center

佐佐木太郎纪念PIXE中心现状报告