Study of the minimally invasive proton therapy combined with anti-cancer drugs and vascular disrupting agents

微创质子治疗联合抗癌药物和血管破坏剂的研究

• 批准号: 20300174
• 负责人: TERAKAWA Atsuki
• 金额: $ 12.81万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20300174/
• 关键词: 粒子線治療; PET; 腫瘍血管標的薬剤; 腫瘍血管標的薬; 腫瘍増殖遅延; 腫瘍血管標的; 薬剤伝達; 腫瘍血管; マイクロパターンガス検出器; 熱音響パルス

The aim of this study was to develop combined treatments between proton therapy and chemotherapy using a vascular targeting agent or an anti-cancer drug which not only kill radio-resistant hypoxia tumor cells effectively but also reduce side effects. We used the novel vascular disrupting agent AVE8062 as a vascular targeting agent, while cisplatin was used as an anti-cancer drag. The results of the therapeutic experiments on a murine solid tumor showed that the proton therapy combined with AVE8062 or cisplatin inhibited tumor growth significantly in comparison to their monotherapies.

本研究的目的是开发质子治疗和化疗之间的联合治疗方法，使用血管靶向剂或抗癌药物，不仅可以有效杀死耐放射缺氧肿瘤细胞，而且可以减少副作用。我们使用新型血管破坏剂AVE8062作为血管靶向剂，而顺铂作为抗癌药物。对小鼠实体瘤的治疗实验结果表明，与单一疗法相比，质子疗法联合AVE8062或顺铂可显着抑制肿瘤生长。

项目成果

Tumor Growth Delay Caused by Proton Therapy in Combination with the Vascular Disrupting Agent AVE8062

质子治疗联合血管破坏剂 AVE8062 引起的肿瘤生长延迟

• 发表时间: 2010
• 期刊: CYRIC Annual Report 2008
• 作者: Kawada T;Sugimachi M.;Terakawa A.
• 通讯作者: Terakawa A.

PIXE ANALYSIS OF A MURINE FIBROSARCOMA TUMOR FOR PROTON THERAPY COMBINED WITH THE CHEMOTHERAPEUTIC AGENT CISPLATIN

质子治疗联合化疗药物顺铂对小鼠纤维肉瘤肿瘤的 PIXE 分析

• 发表时间: 2010
• 期刊: International Journal of PIXE Vol.20 3&4
• 作者: A.TERAKAWA;Y.ITO;K.ISHII;S.MATSUYAMA;Y.KIKUCHI;S.YASUNAGA;A.TAGAWA;T.KAWAMURA;Y.TAKAHASHI;Y.HATORI;N.HAMADA;K.FUJIKI;H.YAMAZAKI;Y.FUNAKI;N.ITO;S.WADA;K.SERA
• 通讯作者: K.SERA

PIXE STUDY ON ABSORPTION OF ARSENATE AND ARSENITE BY ARSENIC HYPER ACCUMULATING FERN

砷超富集蕨类植物吸收砷酸盐和亚砷酸盐的PIXE研究

• 发表时间: 2008
• 期刊: International Journal of PIXE 18
• 作者: Sugimachi M;Sunagawa K;Uemura K;Shishido T.;H. Yamazaki
• 通讯作者: H. Yamazaki

陽子線治療の現状

质子治疗的现状

• 发表时间: 2023
• 期刊: 臨床放射腺
• 作者: Mitsuharu Kimura;Ibuki Onishi;Yumi Yamamoto;Yohei Saito;Hiroshi Fukuda;Akira Makino;Yasushi Kiyono;Hideo Saji;Eiichi Ozeki;Shunsaku Kimura;Fumihiko Yamamoto;荻野浩幸
• 通讯作者: 荻野浩幸

陽子線治療における生物学的効果比に基づく拡大ブラッグピーク形成

质子束治疗中基于生物功效比的扩展布拉格峰形成

• 发表时间: 2009
• 作者: A.Terakawa;伊藤友紀;寺川貴樹;寺川貴樹;寺川貴樹;秋山久樹
• 通讯作者: 秋山久樹