Establishment of a novel therapeutic approach targeting cancer stem cells of neuroblastoma using onclytic virus

利用溶瘤病毒建立针对神经母细胞瘤癌症干细胞的新型治疗方法

• 批准号: 22591976
• 负责人: YOSHIDA Hideo
• 金额: $ 2.83万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591976/
• 关键词: 神経芽腫; 腫瘍融解ウイルス; がん幹細胞; ヘルペスウイルス１型; 癌幹細胞; sphere形成細胞; 抗癌剤耐性

Cancer stem cells have potentials of self-renewal and differentiate. Cancer stem cell-like cells could be extracted through the sphere culture method. Neuroblastoma cell line IMR32 and sIMR32 (cells extracted through sphere culture) were compared for chemosensitivity. IMR32 were more susceptible to cisplatin treatment. However, there was no difference in the cytotoxicity by HSV-1.

癌干细胞具有自我更新和分化的潜力。可以通过球体培养方法提取癌症干细胞样细胞。比较了神经母细胞瘤细胞系IMR32和SIMR32（通过球体培养提取的细胞）的化学敏感性。 IMR32更容易接受顺铂治疗。但是，HSV-1的细胞毒性没有差异。

项目成果

Review of surgical treatment in patients enrolled in the JNBSG high risk neuroblastoma clinical trial (A phase II study of multidisciplinary approach to establish standard treatment for advanced neuroblastoma) A report from Japan Neuroblatoma Study Group

JNBSG高危神经母细胞瘤临床试验（一项多学科方法建立晚期神经母细胞瘤标准治疗的II期研究）患者手术治疗回顾日本神经母细胞瘤研究组的报告

• 发表时间: 2012
• 作者: 菱 木 知 郎;ほ か
• 通讯作者: ほ か

Src kinase family inhibitor PP2 induces aggregation and detachment of neuroblastoma cells and inhibits cell growth in a PI3 kinase/Akt pathway-independent manner

• DOI: 10.1007/s00383-010-2775-2
• 发表时间: 2011-02-01
• 期刊: PEDIATRIC SURGERY INTERNATIONAL
• 影响因子: 1.8
• 作者: Hishiki, Tomoro;Saito, Takeshi;Yoshida, Hideo
• 通讯作者: Yoshida, Hideo

Molecular and genetic bases of neuroblastoma

• DOI: 10.1007/s10147-012-0415-7
• 发表时间: 2012-06-01
• 期刊: INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 3.3
• 作者: Kamijo, Takehiko;Nakagawara, Akira
• 通讯作者: Nakagawara, Akira

小児悪性固形腫瘍に対するNKT細胞系を用いた新規免疫療法の開発研究

使用NKT细胞系治疗儿童恶性实体瘤的新型免疫疗法的研发

• 发表时间: 2013
• 作者: Nakamura Y;Hamada Y;Takada K;Kwon AH;水野誠司，橋本真帆，菱川容子，木村礼子，山田憲一郎，山田裕一，若松延昭;村尾尚規，池田正起，林 利彦，山本有平;菱木知郎
• 通讯作者: 菱木知郎

Review of surgical treatment in patients enrolled in the JNBSG high risk neuroblastoma clinical trial (A phase II study of multidisciplinary approach to establish standard treatment for advanced neuroblastoma) ̶ A report from Japan Neuroblatoma Study Grou

参加 JNBSG 高危神经母细胞瘤临床试验（建立晚期神经母细胞瘤标准治疗的多学科方法的 II 期研究）患者的手术治疗回顾 — 日本神经母细胞瘤研究组的报告

• 作者: 寺師浩人;前重伯壮;野村正;宇佐美眞;菱木 知郎
• 通讯作者: 菱木 知郎