The effect of adipocytokines on retinal circulation in patients with type 2 diabetes

脂肪细胞因子对2型糖尿病患者视网膜循环的影响

• 批准号: 22591961
• 负责人: NAGAOKA Taiji
• 金额: $ 2.75万
• 依托单位: Asahikawa Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591961/
• 关键词: 網膜血流; 血管内皮機能; 一酸化窒素; 糖尿病網膜症; 網膜循環; 血管内皮機能障害; 酸化ストレス; 血糖コントロール

1) Basic Research We have reported that fenofibrate and cilostazol cause vasodilation and that homocystein impairs endothelial function of isolated porcine retinal arterioles. In addition, we also have reported that retinal endothelium, by releasing vasoactive substances, contributes to RBF regulation during acute severe elevation of systemic blood pressure in in vivo cat model.2) Clinical Study We have found that retinal blood flow was decreased in patients with type 2 diabetes and renal dysfunction and that systemic endothelial function was impaired in patients with branch retinal vein occlusion.

1）基础研究，我们报道了拟诺纤维纤维和西洛唑唑引起血管舒张，同囊层会损害分离的猪视网膜小动脉的内皮功能。此外，我们还报道说，视网膜内皮通过释放血管活性物质，在体内CAT模型中急性严重的全身性血压升高期间有助于RBF调节。2）临床研究，我们发现，视网膜血液流量减少了视网膜血流2型糖尿病和肾功能障碍，并且在分支视网膜静脉阻塞的患者中，系统性内皮功能受损。

项目成果

Fenofibrate, an Anti-Dyslipidemia Drug, Elicits the Dilation of Isolated Porcine Retinal Arterioles: Role of Nitric Oxide and AMP-Activated Protein Kinase

• DOI: 10.1167/iovs.11-8841
• 发表时间: 2012-05-01
• 期刊: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
• 影响因子: 4.4
• 作者: Omae, Tsuneaki;Nagaoka, Taiji;Yoshida, Akitoshi
• 通讯作者: Yoshida, Akitoshi

Homocysteine Inhibition of Endothelium-Dependent Nitric Oxide-Mediated Dilation of Porcine Retinal Arterioles via Enhanced Superoxide Production

• DOI: 10.1167/iovs.12-11082
• 发表时间: 2013-03-01
• 期刊: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
• 影响因子: 4.4
• 作者: Omae, Tsuneaki;Nagaoka, Taiji;Yoshida, Akitoshi
• 通讯作者: Yoshida, Akitoshi

Yoshida A. Retinal arteriolar responses to acute severe elevation in systemic blood pressure in cats: Role of endothelium-derived factors

Yoshida A. 猫视网膜动脉对全身血压急性严重升高的反应：内皮衍生因子的作用

• 期刊: Exp Eye Res
• 影响因子: 3.4
• 作者: Nakabayashi S;Nagaoka T^*;Tani T;Sogawa K;Hein TW;Kuo L;Yoshida A
• 通讯作者: Yoshida A

Relationship between retinal blood flow and renal function in patients with type 2 diabetes and chronic kidney disease.

• DOI: 10.2337/dc12-0864
• 发表时间: 2013-04
• 期刊: Diabetes care
• 影响因子: 16.2
• 作者: Nagaoka T;Yoshida A
• 通讯作者: Yoshida A

眼循環測定の有用性と眼血流イメージングを用いた眼循環評価の可能性

眼循环测量的有用性以及利用眼血流成像评估眼循环的可能性

• 发表时间: 2010
• 作者: Kawasaki R;Wong TY、Ed. Yogesan K;Goldschmidt L;Cuadros J;Nagaoka T;Nagaoka T;長岡泰司
• 通讯作者: 長岡泰司